Chapter 8. The Development of a Green, Energy Efficient, Chemoenzymatic Manufacturing Process for Pregabalin

  1. Dr. Peter J. Dunn3,4,
  2. Dr. Andrew S. Wells5 and
  3. Dr. Michael T. Williams6
  1. Dr. Peter J. Dunn3,4,
  2. Kevin Hettenbach1,
  3. Patrick Kelleher2 and
  4. Carlos A. Martinez1

Published Online: 19 MAR 2010

DOI: 10.1002/9783527629688.ch8

Green Chemistry in the Pharmaceutical Industry

Green Chemistry in the Pharmaceutical Industry

How to Cite

Dunn, P. J., Hettenbach, K., Kelleher, P. and Martinez, C. A. (2010) The Development of a Green, Energy Efficient, Chemoenzymatic Manufacturing Process for Pregabalin, in Green Chemistry in the Pharmaceutical Industry (eds P. J. Dunn, A. S. Wells and M. T. Williams), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527629688.ch8

Editor Information

  1. 3

    Pfizer Green Chemistry Lead, Ramsgate Road, Sandwich, Kent, CT13 9NJ, United Kingdom

  2. 4

    Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent, CT13 9NJ, UK

  3. 5

    Astra Zeneca, Process Research & Development, Bakewell Road, Loughborough, LE11 5RH, United Kingdom

  4. 6

    CMC Consultant, 133, London Road, Deal, Kent, CT14 9TY, United Kingdom

Author Information

  1. 1

    Pfizer Global R&D, Chemical R&D Department, MS 4073, Eastern Point Road, Groton, CT 06340, USA

  2. 2

    Pfizer Global Manufactuing, Process Development Centre, Loughbeg, Ireland

  3. 3

    Pfizer Green Chemistry Lead, Ramsgate Road, Sandwich, Kent, CT13 9NJ, United Kingdom

  4. 4

    Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent, CT13 9NJ, UK

Publication History

  1. Published Online: 19 MAR 2010
  2. Published Print: 10 MAR 2010

ISBN Information

Print ISBN: 9783527324187

Online ISBN: 9783527629688

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Keywords:

  • pregabalin;
  • biocatalysis;
  • asymmetric hydrogenation

Summary

This chapter contains sections titled:

  • Introduction

  • Process Routes to Pregabalin

  • Biocatalytic Route to Pregabalin

  • Green Chemistry Considerations

  • Conclusions

  • Acknowledgments

  • References