Chapter 16. Clevudine, to Treat Hepatitis B Viral Infection

  1. Prof. Dr. János Fischer2 and
  2. Prof. Dr. C. Robin Ganellin3
  1. Ashoke Sharon PhD Senior Lecturer,
  2. Ashok K. Jha PhD research scientist and
  3. Professor Chung K. Chu PhD assistant professor Distinguished Research Professor Director

Published Online: 30 AUG 2010

DOI: 10.1002/9783527630035.ch16

Analogue-Based Drug Discovery II

Analogue-Based Drug Discovery II

How to Cite

Sharon, A., Jha, A. K. and Chu, C. K. (2010) Clevudine, to Treat Hepatitis B Viral Infection, in Analogue-Based Drug Discovery II (eds J. Fischer and C. R. Ganellin), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527630035.ch16

Editor Information

  1. 2

    Richter Plc, Gyömröi ut 30, 1103 Budapest, Hungary

  2. 3

    University College London, Department of Chemistry, 20 Gordon Street, London WC1H OAJ, United Kingdom

Author Information

  1. The University of Georgia, College of Pharmacy, Athens, GA 30602, USA

Publication History

  1. Published Online: 30 AUG 2010
  2. Published Print: 21 JUL 2010

ISBN Information

Print ISBN: 9783527325498

Online ISBN: 9783527630035

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Keywords:

  • anti-HBV agent;
  • HBsAg;
  • hepatitis B virus;
  • hepatocellular carcinoma;
  • nucleoside analogue;
  • viral core;
  • viral replication

Summary

This chapter contains sections titled:

  • Current Status of Anti-HBV Agents

  • Chemical Evolution of Clevudine

  • Metabolism and Mechanism of Action

  • Pharmacokinetics

  • Clinical Studies

  • Drug Resistance

  • Toxicity and Tolerability

  • Dosage and Administration

  • Combination Therapy

  • Summary

  • References