Chapter 16. Cardiac and Vascular Manifestations

  1. Dr. David J. Kwiatkowski3,
  2. Dr. Vicky Holets Whittemore4 and
  3. Dr. Elizabeth A. Thiele5
  1. Sergiusz Jóźwiak1 and
  2. Maria Respondek-Liberska2

Published Online: 9 JUN 2010

DOI: 10.1002/9783527630073.ch16

Tuberous Sclerosis Complex: Genes, Clinical Features and Therapeutics

Tuberous Sclerosis Complex: Genes, Clinical Features and Therapeutics

How to Cite

Jóźwiak, S. and Respondek-Liberska, M. (2010) Cardiac and Vascular Manifestations, in Tuberous Sclerosis Complex: Genes, Clinical Features and Therapeutics (eds D. J. Kwiatkowski, V. H. Whittemore and E. A. Thiele), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527630073.ch16

Editor Information

  1. 3

    Brigham & Women's Hospital, Dana Farber Cancer Institute, Harvard Medical School, 1 Blackfan Circle, Boston, MA 02115, USA

  2. 4

    Tuberous Sclerosis Alliance, 801 Roeder Road, Silver Spring, MD 20910, USA

  3. 5

    Carol & James Herscot Center For TCS, Massachusetts General Hospital, Department of Neurology, 175 Cambridge Street, Boston, MA 02114, USA

Author Information

  1. 1

    The Children's Memorial Health Institute Department of Pediatric Neurology and Epileptology Warsaw Poland

  2. 2

    Medical University of Lódzź; and Research Institute Polish Mother's, Memorial Hospital, Department for Diagnosis and Prevention of Fetal Malformations, Lódź, Poland

Publication History

  1. Published Online: 9 JUN 2010
  2. Published Print: 21 APR 2010

ISBN Information

Print ISBN: 9783527322015

Online ISBN: 9783527630073



  • aneurysm;
  • cardiac rhabdomyoma;
  • cardiomyopathy;
  • congestive heart failure;
  • tuberous sclerosis complex;
  • WPW syndrome


This chapter contains sections titled:

  • Introduction

  • Prevalence and Natural History of Cardiac Rhabdomyomas

  • Clinical Manifestations

  • Pathology and Molecular Biology of Cardiac Tumors

  • Diagnosis

  • Fetal Cardiac Rhabdomyomas and Diagnosis of TSC

  • Treatment

  • Genotype–Phenotype Correlations with Rhabdomyomas

  • Vascular Abnormalities in TSC

  • References