Chapter 6. The Role of Target of Rapamycin Signaling in Tuberous Sclerosis Complex

  1. Dr. David J. Kwiatkowski2,
  2. Dr. Vicky Holets Whittemore3 and
  3. Dr. Elizabeth A. Thiele4
  1. Brendan D. Manning

Published Online: 9 JUN 2010

DOI: 10.1002/9783527630073.ch6

Tuberous Sclerosis Complex: Genes, Clinical Features and Therapeutics

Tuberous Sclerosis Complex: Genes, Clinical Features and Therapeutics

How to Cite

Manning, B. D. (2010) The Role of Target of Rapamycin Signaling in Tuberous Sclerosis Complex, in Tuberous Sclerosis Complex: Genes, Clinical Features and Therapeutics (eds D. J. Kwiatkowski, V. H. Whittemore and E. A. Thiele), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527630073.ch6

Editor Information

  1. 2

    Brigham & Women's Hospital, Dana Farber Cancer Institute, Harvard Medical School, 1 Blackfan Circle, Boston, MA 02115, USA

  2. 3

    Tuberous Sclerosis Alliance, 801 Roeder Road, Silver Spring, MD 20910, USA

  3. 4

    Carol & James Herscot Center For TCS, Massachusetts General Hospital, Department of Neurology, 175 Cambridge Street, Boston, MA 02114, USA

Author Information

  1. Harvard University, School of Public Health, Department of Genetics and Complex Diseases, Boston, MA 02115, USA

Publication History

  1. Published Online: 9 JUN 2010
  2. Published Print: 21 APR 2010

ISBN Information

Print ISBN: 9783527322015

Online ISBN: 9783527630073

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Keywords:

  • insulin;
  • insulin receptor substrate;
  • phosphatidylinositol 3-kinase;
  • rapamycin;
  • all growth;
  • tuberous sclerosis complex

Summary

This chapter contains sections titled:

  • The Target of Rapamycin: An Evolutionarily Conserved Regulator of Cell Growth and Proliferation

  • Genetic and Biochemical Studies Link the TSC1–TSC2 Complex to Cell Growth Control Through mTORC1

  • The TSC1–TSC2 Complex as a Critical Sensor of Cellular Growth Conditions

  • Primary mTOR-Related Signaling Defects Triggered by Disruption of the TSC1–TSC2 Complex

  • Pathological Consequences of mTOR Dysregulation in TSC

  • Therapeutic Opportunities: Rapamycin and Beyond

  • References