Chapter 8. Animal Models of TSC: Insights from Drosophila

  1. Dr. David J. Kwiatkowski2,
  2. Dr. Vicky Holets Whittemore3 and
  3. Dr. Elizabeth A. Thiele4
  1. Duojia Pan

Published Online: 9 JUN 2010

DOI: 10.1002/9783527630073.ch8

Tuberous Sclerosis Complex: Genes, Clinical Features and Therapeutics

Tuberous Sclerosis Complex: Genes, Clinical Features and Therapeutics

How to Cite

Pan, D. (2010) Animal Models of TSC: Insights from Drosophila, in Tuberous Sclerosis Complex: Genes, Clinical Features and Therapeutics (eds D. J. Kwiatkowski, V. H. Whittemore and E. A. Thiele), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527630073.ch8

Editor Information

  1. 2

    Brigham & Women's Hospital, Dana Farber Cancer Institute, Harvard Medical School, 1 Blackfan Circle, Boston, MA 02115, USA

  2. 3

    Tuberous Sclerosis Alliance, 801 Roeder Road, Silver Spring, MD 20910, USA

  3. 4

    Carol & James Herscot Center For TCS, Massachusetts General Hospital, Department of Neurology, 175 Cambridge Street, Boston, MA 02114, USA

Author Information

  1. Johns Hopkins University School of Medicine, Howard Hughes Medical Institute, Department of Molecular Biology and Genetics, Baltimore, MD 21205, USA

Publication History

  1. Published Online: 9 JUN 2010
  2. Published Print: 21 APR 2010

ISBN Information

Print ISBN: 9783527322015

Online ISBN: 9783527630073

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Keywords:

  • autophagy;
  • Drosophila genome;
  • insulin pathway;
  • phosphorylation;
  • rapamycin;
  • tumor suppressor

Summary

This chapter contains sections titled:

  • Introduction

  • Connecting TSC1–TSC2 to the Insulin/PI3K Signaling Pathway

  • The Tsc1–Tsc2 Complex as a Negative Regulator of TORC1

  • Identification of the Small GTPase Rheb as a Direct Target of the Tsc1–Tsc2 Complex

  • Control of Autophagy by the Tsc–Rheb–TORC1 Pathway

  • Cross Talk Between the Tsc–Rheb–TORC1 Pathway and the Insulin Pathway

  • Relationship Between Tsc1–Tsc2 and Amino Acids-Mediated TORC1 Activation

  • Upstream of the Tsc1–Tsc2 Complex

  • Summary

  • References