8. Genotoxic Estrogen Pathway: Endogenous and Equine Estrogen Hormone Replacement Therapy

  1. Prof. Nicholas E. Geacintov2 and
  2. Prof. Suse Broyde3
  1. Judy L. Bolton and
  2. Gregory R. J. Thatcher

Published Online: 11 OCT 2010

DOI: 10.1002/9783527630110.ch8

The Chemical Biology of DNA Damage

The Chemical Biology of DNA Damage

How to Cite

Bolton, J. L. and Thatcher, G. R. J. (2010) Genotoxic Estrogen Pathway: Endogenous and Equine Estrogen Hormone Replacement Therapy, in The Chemical Biology of DNA Damage (eds N. E. Geacintov and S. Broyde), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527630110.ch8

Editor Information

  1. 2

    New York University, Chemistry Department, 31 Washington Place, New York, NY 10003-5180, USA

  2. 3

    New York University, Department of Biology, 100 Washington Square, New York, NY 10003-6688, USA

Author Information

  1. University of Illinois at Chicago, College of Pharmacy, Department of Medicinal Chemistry and Pharmacognosy (M/C 781), 833 S. Wood Street, Chicago, IL 60612 - 7231, USA

Publication History

  1. Published Online: 11 OCT 2010
  2. Published Print: 23 JUN 2010

ISBN Information

Print ISBN: 9783527322954

Online ISBN: 9783527630110

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Keywords:

  • estrogen;
  • hormone replacement therapy;
  • carcinogenesis;
  • equilin;
  • equilenin;
  • Premarin®

Summary

This chapter contains sections titled:

  • Risks of Estrogen Exposure

  • Mechanisms of Estrogen Carcinogenesis

  • Estrogen Receptor as a Trojan Horse (Combined Hormonal/Chemical Mechanism)

  • Conclusions and Future Directions

  • Acknowledgements

  • References