15. Synergy: A Risk Management Perspective

  1. Dr. Moiz Mumtaz
  1. Paul S. Price

Published Online: 28 DEC 2010

DOI: 10.1002/9783527630196.ch15

Principles and Practice of Mixtures Toxicology

Principles and Practice of Mixtures Toxicology

How to Cite

Price, P. S. (2010) Synergy: A Risk Management Perspective, in Principles and Practice of Mixtures Toxicology (ed M. Mumtaz), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527630196.ch15

Editor Information

  1. Agency for Toxic Substances and Disease Registry (ATSDR), Computational Toxicology and Methods, Development Laboratory, Division of Toxicology and Environmental Medicine, MS-F62, 1600 Clifton Road, Atlanta, GA 30333, USA

Author Information

  1. The Dow Chemical Company, Toxicology & Environmental Research and Consulting, 2030 Dow Center, Midland, MI 48674, USA

Publication History

  1. Published Online: 28 DEC 2010
  2. Published Print: 25 AUG 2010

ISBN Information

Print ISBN: 9783527319923

Online ISBN: 9783527630196

SEARCH

Keywords:

  • complex mixtures;
  • critical effect;
  • reference dose;
  • relative potency factor;
  • risk management;
  • chronic;
  • sensitive human NOAEL;
  • interaction threshold

Summary

This chapter contains sections titled:

  • Introduction

  • Synergy

  • Risk Management and Synergy

  • Models of Mixture Toxicity

  • Placing Doses Used in Studies Demonstrating Synergy into a Risk Management Framework

  • Extending the Approach to Mixtures of Three or More Chemicals

  • Using the Graphic Framework to Place Data on Synergy into a Risk Management Context

  • Doses of Mixture Components Permitted Under Current Models of Mixture Risks for Humans

  • Relationship between Toxicity and Synergistic Potential

  • Discussion

  • Summary and Conclusions

  • Acknowledgment

  • References