2. Chemical Mixtures in the Environment: Exposure Assessment

  1. Dr. Moiz Mumtaz
  1. Glenn Rice1 and
  2. Margaret MacDonell2

Published Online: 28 DEC 2010

DOI: 10.1002/9783527630196.ch2

Principles and Practice of Mixtures Toxicology

Principles and Practice of Mixtures Toxicology

How to Cite

Rice, G. and MacDonell, M. (2010) Chemical Mixtures in the Environment: Exposure Assessment, in Principles and Practice of Mixtures Toxicology (ed M. Mumtaz), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527630196.ch2

Editor Information

  1. Agency for Toxic Substances and Disease Registry (ATSDR), Computational Toxicology and Methods, Development Laboratory, Division of Toxicology and Environmental Medicine, MS-F62, 1600 Clifton Road, Atlanta, GA 30333, USA

Author Information

  1. 1

    U.S. Environmental Protection Agency, Office of Research and Development, National Center for Environmental Assessment Chemical Risk Assessment Branch Chemical Mixtures Research Team, 26 West Martin Luther King Drive, M.S. A 130 Cincinnati, OH 45268, USA

  2. 2

    Argonne National Laboratory, Environmental Science Division, 9700 South Cass Avenue, EVS/Bldg 240, Argonne, IL 60439, USA

Publication History

  1. Published Online: 28 DEC 2010
  2. Published Print: 25 AUG 2010

ISBN Information

Print ISBN: 9783527319923

Online ISBN: 9783527630196



  • exposure pathway;
  • disinfection by-products;
  • Henry's law constant;
  • octanol/water partition coefficient;
  • receiving medium;
  • risk assessment paradigm;
  • toxicokinetics;
  • waste combustion facility


This chapter contains sections titled:

  • Risk Assessment Paradigm: A Chemical Mixtures Context

  • Occurrence of Chemical Mixtures in the Environment

  • Drivers for Assessing Exposures to Chemical Mixtures

  • Using Conceptual Models to Guide the Development of Mixture Exposure Assessments

  • Overview of Environmental Fate for Chemical Mixtures

  • Methods and Applications for Assessing Mixture Exposures

  • Illustrative Example: Assessing Exposures to DBP Mixtures in Drinking Water

  • Summary

  • Future Directions

  • Acknowledgments

  • References