22. The Application of Physiologically Based Pharmacokinetics, Bayesian Population PBPK Modeling, and Biochemical Reaction Network Modeling to Chemical Mixture Toxicology
- Dr. Moiz Mumtaz
Published Online: 28 DEC 2010
Copyright © 2010 Wiley-VCH Verlag GmbH & Co. KGaA
Principles and Practice of Mixtures Toxicology
How to Cite
Yang, R. S. H., Mayeno, A. N., Lyons, M. A. and Reisfeld, B. (2010) The Application of Physiologically Based Pharmacokinetics, Bayesian Population PBPK Modeling, and Biochemical Reaction Network Modeling to Chemical Mixture Toxicology, in Principles and Practice of Mixtures Toxicology (ed M. Mumtaz), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527630196.ch22
Agency for Toxic Substances and Disease Registry (ATSDR), Computational Toxicology and Methods, Development Laboratory, Division of Toxicology and Environmental Medicine, MS-F62, 1600 Clifton Road, Atlanta, GA 30333, USA
- Published Online: 28 DEC 2010
- Published Print: 25 AUG 2010
Print ISBN: 9783527319923
Online ISBN: 9783527630196
- chemical mixture toxicity;
- toxicological interactions;
- PBPK modeling;
- biochemical reaction network modeling;
- multi-scale modeling;
- prediction of chemical mixture toxicity;
- risk assessment of chemical mixtures;
- systems biology approach
This chapter contains sections titled:
Why is Computer Simulation Not Only Important But Also Necessary for Chemical Mixture Toxicology?
What Do We Mean by “Computer Simulation?” What Does it Entail?
What is Physiologically-Based Pharmacokinetic Modeling? How Does it work?
What is Bayesian Inference and Population PBPK Modeling? What is Markov Chain Monte Carlo Simulation? Why Do We Need These Technologies?
What is Biochemical Reaction Network Modeling? Where Did It Come From? How Does It Work? Why Do We Need It for Chemical Mixture Toxicology?
What is “Multiscale Modeling?” How Do PBPK, Bayesian Population PBPK Modeling, and BRN modeling Fit Into “Multiscale Modeling?” Any Possible Inclusion of Other Types of Computer Modeling?
Can We Predict Chemical Mixture Toxicities? What is the Potential Real-World Application of Such a “Multiscale Computer Simulation” Approach?