3. Application of a Relative Potency Factor Approach in the Assessment of Health Risks Associated with Exposures to Mixtures of Dioxin-Like Compounds

  1. Dr. Moiz Mumtaz
  1. Daniele F. Staskal1,
  2. Linda S. Birnbaum2 and
  3. Laurie C. Haws1

Published Online: 28 DEC 2010

DOI: 10.1002/9783527630196.ch3

Principles and Practice of Mixtures Toxicology

Principles and Practice of Mixtures Toxicology

How to Cite

Staskal, D. F., Birnbaum, L. S. and Haws, L. C. (2010) Application of a Relative Potency Factor Approach in the Assessment of Health Risks Associated with Exposures to Mixtures of Dioxin-Like Compounds, in Principles and Practice of Mixtures Toxicology (ed M. Mumtaz), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527630196.ch3

Editor Information

  1. Agency for Toxic Substances and Disease Registry (ATSDR), Computational Toxicology and Methods, Development Laboratory, Division of Toxicology and Environmental Medicine, MS-F62, 1600 Clifton Road, Atlanta, GA 30333, USA

Author Information

  1. 1

    Tox Strategies, 3420 Executive Center Drive, Suite 114, Austin, TX 78731, USA

  2. 2

    National Institute of Environmental Health Sciences (NIEHS), P.O. Box 12233, Mail Drop B2-01, Research Triangle Park, NC 27709, USA

Publication History

  1. Published Online: 28 DEC 2010
  2. Published Print: 25 AUG 2010

ISBN Information

Print ISBN: 9783527319923

Online ISBN: 9783527630196

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Keywords:

  • aryl hydrocarbon receptor;
  • dioxin-like compounds;
  • dioxin-like congeners;
  • relative potency estimate;
  • relative potency factor;
  • toxic equivalency factor

Summary

This chapter contains sections titled:

  • Dioxin-Like Chemicals

  • Introduction of TEF Methodology

  • Evolution of TEF Approach

  • Relative Potency Estimates

  • Derivation of TEF Values – Past, Present, and Future

  • Assumptions, Limitations, and Uncertainties of the TEF Approach

  • Closing Remarks

  • References