4. Statistical Methods in Risk Assessment of Chemical Mixtures

  1. Dr. Moiz Mumtaz
  1. Chris Gennings

Published Online: 28 DEC 2010

DOI: 10.1002/9783527630196.ch4

Principles and Practice of Mixtures Toxicology

Principles and Practice of Mixtures Toxicology

How to Cite

Gennings, C. (2010) Statistical Methods in Risk Assessment of Chemical Mixtures, in Principles and Practice of Mixtures Toxicology (ed M. Mumtaz), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527630196.ch4

Editor Information

  1. Agency for Toxic Substances and Disease Registry (ATSDR), Computational Toxicology and Methods, Development Laboratory, Division of Toxicology and Environmental Medicine, MS-F62, 1600 Clifton Road, Atlanta, GA 30333, USA

Author Information

  1. Virginia Commonwealth University, Department of Biostatistics, 1101 E. Marshall St., Richmond, VA 23298-0032, USA

Publication History

  1. Published Online: 28 DEC 2010
  2. Published Print: 25 AUG 2010

ISBN Information

Print ISBN: 9783527319923

Online ISBN: 9783527630196

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Keywords:

  • dose-response curve;
  • gait score;
  • isobologram;
  • response variable;
  • SCNR method;
  • SCR method

Summary

This chapter contains sections titled:

  • Principles of Statistics

  • Statistical Approaches for Evaluating Mixtures

  • Alternative Approach: Use of Ray Designs with Focus on Relevant Mixing Ratios

  • Testing for Additivity in the Low-Dose Region

  • Sufficient Similarity in Dose Responsiveness

  • Summary

  • References