5. Modeling Kinetic Interactions of Chemical Mixtures

  1. Dr. Moiz Mumtaz
  1. Jerry L. Campbell Jr.1,
  2. Kannan Krishnan2,3,
  3. Harvey J. Clewell III1 and
  4. Melvin E. Andersen1

Published Online: 28 DEC 2010

DOI: 10.1002/9783527630196.ch5

Principles and Practice of Mixtures Toxicology

Principles and Practice of Mixtures Toxicology

How to Cite

Campbell, J. L., Krishnan, K., Clewell, H. J. and Andersen, M. E. (2010) Modeling Kinetic Interactions of Chemical Mixtures, in Principles and Practice of Mixtures Toxicology (ed M. Mumtaz), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527630196.ch5

Editor Information

  1. Agency for Toxic Substances and Disease Registry (ATSDR), Computational Toxicology and Methods, Development Laboratory, Division of Toxicology and Environmental Medicine, MS-F62, 1600 Clifton Road, Atlanta, GA 30333, USA

Author Information

  1. 1

    The Hamner Institutes for Health Research, P.O. Box 12137, Research Triangle Park, NC 27709, USA

  2. 2

    Université de Montréal, Département de santé environnementale et santé au travail, C.P. 6128, Succ. Centre-ville, Montréal (Québec) H3C 3J7, Canada

  3. 3

    UMDNJ/Rutgers University, Environmental and Occupational Health Sciences Institute, 170 Frelinghuysen Road, Piscataway, NJ 08854, USA

Publication History

  1. Published Online: 28 DEC 2010
  2. Published Print: 25 AUG 2010

ISBN Information

Print ISBN: 9783527319923

Online ISBN: 9783527630196

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Keywords:

  • biotransformation;
  • metabolic rate constants;
  • PBPK modeling;
  • pharmacokinetic behavior;
  • skin permeability constant;
  • tissue:blood partition coefficient

Summary

This chapter contains sections titled:

  • Pharmacokinetic Modeling

  • PBPK Modeling of Individual Chemicals

  • PBPK Modeling of Binary Chemical Mixtures

  • PBPK Modeling of Complex Chemical Mixtures

  • Summary and Future Directions

  • References