6. Toxicodynamic Interactions

  1. Dr. Moiz Mumtaz
  1. Binu K. Philip1,
  2. S. Satheesh Anand2 and
  3. Harihara M. Mehendale3

Published Online: 28 DEC 2010

DOI: 10.1002/9783527630196.ch6

Principles and Practice of Mixtures Toxicology

Principles and Practice of Mixtures Toxicology

How to Cite

Philip, B. K., Anand, S. S. and Mehendale, H. M. (2010) Toxicodynamic Interactions, in Principles and Practice of Mixtures Toxicology (ed M. Mumtaz), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527630196.ch6

Editor Information

  1. Agency for Toxic Substances and Disease Registry (ATSDR), Computational Toxicology and Methods, Development Laboratory, Division of Toxicology and Environmental Medicine, MS-F62, 1600 Clifton Road, Atlanta, GA 30333, USA

Author Information

  1. 1

    Indiana University, School of Medicine, 1120 South Drive, Indianapolis, IN 46202, USA

  2. 2

    DuPont Haskell, Global Centers for Health and Environmental Sciences, Newark, DE 19714, USA

  3. 3

    University of Louisiana at Monroe, College of Pharmacy, Department of Toxicology, Bienville Building, 700 University Avenue, Monroe, LA 71209, USA

Publication History

  1. Published Online: 28 DEC 2010
  2. Published Print: 25 AUG 2010

ISBN Information

Print ISBN: 9783527319923

Online ISBN: 9783527630196



  • Chemical mixture;
  • dose-response;
  • rise assessment;
  • toxic outcome;
  • tissue repair;
  • toxicodynamic interactions


This chapter contains sections titled:

  • Introduction

  • Historical Perspective of Chemical Mixtures

  • Current Status

  • Tissue Repair

  • Interactions Leading to Increased Liver Injury, But Not Death

  • Two-Stage Model of Toxicity

  • Tissue Repair Follows a Dose Response After Exposure to Chemical Mixtures

  • Tissue Repair Determines the Outcome of Toxicity

  • Molecular and Cellular Mechanisms of Tissue Repair

  • Implications for Risk Assessment

  • Conclusions

  • References