Chapter 7. Dopamine and the Electrophysiology of Prefrontal Cortical Networks

  1. Prof. Dr. Felix Tretter2,
  2. Prof. Dr. Peter J. Gebicke-Haerter3,
  3. Dr. Eduardo R. Mendoza4,5 and
  4. Prof. Dr. Georg Winterer6
  1. Patricio O'Donnell

Published Online: 14 JUL 2010

DOI: 10.1002/9783527630271.ch7

Systems Biology in Psychiatric Research: From High-Throughput Data to Mathematical Modeling

Systems Biology in Psychiatric Research: From High-Throughput Data to Mathematical Modeling

How to Cite

O'Donnell, P. (2010) Dopamine and the Electrophysiology of Prefrontal Cortical Networks, in Systems Biology in Psychiatric Research: From High-Throughput Data to Mathematical Modeling (eds F. Tretter, P. J. Gebicke-Haerter, E. R. Mendoza and G. Winterer), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527630271.ch7

Editor Information

  1. 2

    Isar-Amper-Klinikum GmbH, Klinikum München Ost, Vockestrasse 72, 85540 Haar, Germany

  2. 3

    Department for Psychopharmacology, Central Institute of Mental Health, J5, 68159 Mannheim, Germany

  3. 4

    Ludwigs Maximilian University Munich, Department of Physics, Geschwister-Scholl-Platz 1, 80539 Munich, Germany

  4. 5

    University of the Philippines Diliman, Institute of Mathematics, C.P. Garcia Street, 1101 Quezon City, Philippines

  5. 6

    University of Düsseldorf, Psychiatric Hospital, Bergische Landstrasse 2, 40629 Düsseldorf, Germany

Author Information

  1. University of Maryland School of Medicine, Department of Anatomy & Neurobiology, 20 Penn Street, Baltimore, MD 21201, USA

Publication History

  1. Published Online: 14 JUL 2010
  2. Published Print: 21 APR 2010

ISBN Information

Print ISBN: 9783527325030

Online ISBN: 9783527630271

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Keywords:

  • prefrontal cortex;
  • dopamine;
  • Nmethyl-d-aspartate;
  • γ-aminobutyric acid;
  • interneuron;
  • D1;
  • D2;
  • schizophrenia;
  • animal models

Summary

This chapter contains sections titled:

  • Introduction

  • Electrophysiological Actions of DA in Prefrontal Cortical Circuits

  • Changes in DA Modulation of Pyramidal Neurons during Adolescence

  • Changes in DA Modulation of GABA Interneurons during Adolescence

  • Abnormal Periadolescent Maturation of DA Actions in Developmental Animal Models of Schizophrenia

  • Implications for Schizophrenia Pathophysiology and Novel Treatments

  • References