Chapter 1. The Role of Copper Ion and the Ubiquitin System in Neurodegenerative Disorders

  1. Prof. Bruno Pignataro
  1. Fabio Arnesano

Published Online: 9 JUN 2010

DOI: 10.1002/9783527630516.ch1

Ideas in Chemistry and Molecular Sciences: Where Chemistry Meets Life

Ideas in Chemistry and Molecular Sciences: Where Chemistry Meets Life

How to Cite

Arnesano, F. (2010) The Role of Copper Ion and the Ubiquitin System in Neurodegenerative Disorders, in Ideas in Chemistry and Molecular Sciences: Where Chemistry Meets Life (ed B. Pignataro), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527630516.ch1

Editor Information

  1. University of Palermo, Department of Physical Chemistry, Viale delle Scienze, 90128 Palermo, Italy

Author Information

  1. University of Bari “A. Moro”, Department of Farmaco-Chimico, Via E. Orabona 4, 70125 Bari, Italy

Publication History

  1. Published Online: 9 JUN 2010
  2. Published Print: 24 MAR 2010

ISBN Information

Print ISBN: 9783527325412

Online ISBN: 9783527630516

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Keywords:

  • ubiquitin;
  • brain copper homeostasis;
  • protofibrils;
  • dehydrons;
  • neurodegenerative disorders

Summary

This chapter contains sections titled:

  • Introduction

  • Metal Ions in the Brain

  • Brain Copper Homeostasis

  • Brain Copper and Neurodegenerative Disorders

  • The Role of Ubiquitin in Protein Degradation

  • Failure of the Ubiquitin System in Neurodegenerative Disorders

  • Interaction of Ubiquitin with Metal Ions

  • Biological Implications

  • Conclusions and Perspectives

  • Acknowledgments

  • References