Chapter 7. Structure-Based Design on the Way to New Anti-Infectives

  1. Prof. Bruno Pignataro
  1. Anna Katharina Herta Hirsch

Published Online: 9 JUN 2010

DOI: 10.1002/9783527630516.ch7

Ideas in Chemistry and Molecular Sciences: Where Chemistry Meets Life

Ideas in Chemistry and Molecular Sciences: Where Chemistry Meets Life

How to Cite

Katharina Herta Hirsch, A. (2010) Structure-Based Design on the Way to New Anti-Infectives, in Ideas in Chemistry and Molecular Sciences: Where Chemistry Meets Life (ed B. Pignataro), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527630516.ch7

Editor Information

  1. University of Palermo, Department of Physical Chemistry, Viale delle Scienze, 90128 Palermo, Italy

Author Information

  1. Université de Strasbourg, Institut de Science et d'Ingénierie, Supramoléculaires, 8 Allée Gaspard Monge, Strasbourg 67000, France

Publication History

  1. Published Online: 9 JUN 2010
  2. Published Print: 24 MAR 2010

ISBN Information

Print ISBN: 9783527325412

Online ISBN: 9783527630516

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Keywords:

  • anti-infective agents;
  • cocrystal structure analysis;
  • kinase;
  • nonmevalonate pathway;
  • molecular recognition;
  • structure-based inhibitor design

Summary

This chapter contains sections titled:

  • Introduction

  • Isoprenoids and the Nonmevalonate Pathway

  • Targeting the CDP-Binding Pocket of IspE

  • X-ray Cocrystal Structure Analysis

  • Conclusions and Outlook

  • Acknowledgments

  • List of Abbreviations

  • References