2. Cytochromes P450

  1. Prof. Pavel Anzenbacher2,3 and
  2. Prof. Dr. Ulrich M. Zanger4
  1. F. Peter Guengerich

Published Online: 4 JUN 2012

DOI: 10.1002/9783527630905.ch2

Metabolism of Drugs and Other Xenobiotics

Metabolism of Drugs and Other Xenobiotics

How to Cite

Guengerich, F. P. (2012) Cytochromes P450, in Metabolism of Drugs and Other Xenobiotics (eds P. Anzenbacher and U. M. Zanger), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527630905.ch2

Editor Information

  1. 2

    Palacky University at Olomouc, Dept. Pharmacology, Hnevotinska str. 3, 779 00 Olomouc, Czech Republic

  2. 3

    Palacky University at Olomouc, Faculty of Medicine and Dentistry, Department of Pharmacology and Inst. Mol. and Translational Medicine, Hnevotinska st. 3, Olomouc, 775 15, Czech Republic

  3. 4

    Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, University of Stuttgart (IKP), Auerbachstrasse 112, 70376 Stuttgart, Germany

Author Information

  1. Vanderbilt University School of Medicine, Department of Biochemistry and Center in Molecular Toxicology, 638 Robinson Research Building, 2200 Pierce Avenue, Nashville, TN 37232-0146, USA

Publication History

  1. Published Online: 4 JUN 2012
  2. Published Print: 18 APR 2012

ISBN Information

Print ISBN: 9783527329038

Online ISBN: 9783527630905

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Keywords:

  • cytochrome P450;
  • gene;
  • nomenclature;
  • regulation;
  • polymorphism;
  • structure;
  • catalysis;
  • drug;
  • metabolism

Summary

This chapter contains sections titled:

  • Introduction and Historical Perspective

  • Nomenclature and Gene Organization

  • Regulation

  • Polymorphisms

  • Protein Structure

  • Catalytic Mechanisms

  • What Determines P450 Catalytic Selectivity?

  • Oxidative Stress and P450s

  • Relevance in Drug Metabolism and Clinical Medicine

  • References