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13. Chemoselective Peptide Ligation: A Privileged Tool for Protein Synthesis

  1. Andrew B. Hughes
  1. Christian P. R. Hackenberger1,
  2. Jeffrey W. Bode2,
  3. Dirk Schwarzer3

Published Online: 31 JAN 2011

DOI: 10.1002/9783527631803.ch13

Amino Acids, Peptides and Proteins in Organic Chemistry: Building Blocks, Catalysis and Coupling Chemistry, Volume 3

Amino Acids, Peptides and Proteins in Organic Chemistry: Building Blocks, Catalysis and Coupling Chemistry, Volume 3

How to Cite

Hackenberger, C. P. R., Bode, J. W. and Schwarzer, D. (2010) Chemoselective Peptide Ligation: A Privileged Tool for Protein Synthesis, in Amino Acids, Peptides and Proteins in Organic Chemistry: Building Blocks, Catalysis and Coupling Chemistry, Volume 3 (ed A. B. Hughes), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527631803.ch13

Editor Information

  1. La Trobe University, Department of Chemistry, Victoria 3086, Australia

Author Information

  1. 1

    Freie Universität Berlin, Institut für Chemie und Biochemie, Takustrasse 3, 14195 Berlin, Germany

  2. 2

    Eidgenössische Technische, Hochschule Zürich, Laboratorium für Organische Chemie, Wolfgang Pauli Strasse 10, 8093 Zürich, Switzerland

  3. 3

    Leibniz-Institut für Molekulare Pharmakologie (FMP), Chemical Biology Section, Robert-Rössle-Strasse 10, 13125 Berlin, Germany

Publication History

  1. Published Online: 31 JAN 2011
  2. Published Print: 15 DEC 2010

ISBN Information

Print ISBN: 9783527321025

Online ISBN: 9783527631803

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Keywords:

  • chemoselectivity;
  • native chemical ligation;
  • peptides;
  • protein ligation;
  • semisynthesis;
  • bioorthogonal

Summary

This chapter contains sections titled:

  • Introduction

  • Chemoselective Peptide Ligations Following a Capture/Rearrangement Strategy

  • Chemical Transformations for Cys-Free Ligations in Peptides and Proteins

  • Other Chemoselective Capture Strategies

  • Peptide Ligations by Chemoselective Amide-Bond-Forming Reactions

  • Strategies for the Ligation of Multiple Fragments

  • References