5. Direct and Indirect Mechanisms of Alcohol Teratogenesis: Implications for Understanding Alterations in Brain and Behavior in FASD

  1. Prof. Dr. Edward P. Riley5,
  2. Prof. Dr. Sterling Clarren6,
  3. Dr. Joanne Weinberg7 and
  4. Prof. Dr. Egon Jonsson8
  1. Kristina A. Uban1,
  2. Tamara Bodnar2,
  3. Kelly Butts3,
  4. Joanna H. Sliwowska4,
  5. Wendy Comeau2 and
  6. Dr. Joanne Weinberg7

Published Online: 15 NOV 2010

DOI: 10.1002/9783527632510.ch5

Fetal Alcohol Spectrum Disorder: Management and Policy Perspectives of FASD, First Edition

Fetal Alcohol Spectrum Disorder: Management and Policy Perspectives of FASD, First Edition

How to Cite

Uban, K. A., Bodnar, T., Butts, K., Sliwowska, J. H., Comeau, W. and Weinberg, J. (2010) Direct and Indirect Mechanisms of Alcohol Teratogenesis: Implications for Understanding Alterations in Brain and Behavior in FASD, in Fetal Alcohol Spectrum Disorder: Management and Policy Perspectives of FASD, First Edition (eds E. P. Riley, S. Clarren, J. Weinberg and E. Jonsson), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527632510.ch5

Editor Information

  1. 5

    San Diego State University, Center for Behavioral Teratology, 6363, Alvarado Ct. #209, San Diego, CA 92120, USA

  2. 6

    University of British Columbia, Faculty of Medicine – Pediatrics, L408 – Oak Street 4480, Vancouver, BC V6H 3V4, Canada

  3. 7

    University of British Columbia, Department of Cellular & Physioloical Scinces, Health Sciences Mall 2350, Vancouver, BC V6T 1Z3, Canada

  4. 8

    University of Alberta, University of Calgary, Department of Public Health Science, Institute of Health Economics, 10405 Jasper Ave, Edmonton, Alberta T5J 3N4, Canada

Author Information

  1. 1

    University of British Columbia, Department of Psychology, 2136 West Mall, Vancouver, Canada BC V6T 1Z4, Canada

  2. 2

    University of British Columbia, Department of Cellular & Physiological Sciences, 2350 Health Sciences Mall, Vancouver, BC, Canada BC V6T 1Z3, Canada

  3. 3

    University of British Columbia, UBC Institute of Mental Health, Department of Psychiatry, 5950 University Blvd, Vancouver, BC, Canada BC V6T 1Z3, Canada

  4. 4

    Poznan University of Life Sciences, Institute of Zoology, Department of Histology and Embryology, ul. Wojska Polskiego 71c, 60 - 625 Poznań, Poland

  5. 7

    University of British Columbia, Department of Cellular & Physioloical Scinces, Health Sciences Mall 2350, Vancouver, BC V6T 1Z3, Canada

Publication History

  1. Published Online: 15 NOV 2010
  2. Published Print: 27 OCT 2010

ISBN Information

Print ISBN: 9783527328390

Online ISBN: 9783527632510

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Keywords:

  • Animal models of FASD;
  • hypothalamic–pituitary–adrenal (HPA) axis;
  • stress;
  • depression;
  • substance use;
  • fetal programming;
  • epigenetics;
  • immune system

Summary

This chapter contains sections titled:

  • Introduction

  • Fetal Programming: Programming of the HPA Axis by PAE

  • Altered Epigenetic Regulation of Gene Expression: A Possible Mechanism Underlying Fetal Programming of the HPA Axis and Altered Neuroendocrine-Immune Interactions

  • Prenatal Alcohol Exposure: Early Experience, Stress Responsiveness, and Vulnerability to Depression

  • FASD and Substance Abuse

  • Summary and Policy Considerations

  • Acknowledgments

  • Glossary

  • Abbreviations

  • References