3. Current Status and Mechanism of Action of Platinum-Based Anticancer Drugs

  1. Prof. Dr. Enzo Alessio
  1. Shanta Dhar and
  2. Stephen J. Lippard

Published Online: 23 FEB 2011

DOI: 10.1002/9783527633104.ch3

Bioinorganic Medicinal Chemistry

Bioinorganic Medicinal Chemistry

How to Cite

Dhar, S. and Lippard, S. J. (2011) Current Status and Mechanism of Action of Platinum-Based Anticancer Drugs, in Bioinorganic Medicinal Chemistry (ed E. Alessio), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527633104.ch3

Editor Information

  1. University of Trieste, Department of Chemical Sciences, Via Giorgieri 1, 34127 Trieste, Italy

Author Information

  1. Massachusetts Institute of Technology, Department of Chemistry, Room 18-498, Cambridge, MA 02139, USA

Publication History

  1. Published Online: 23 FEB 2011
  2. Published Print: 26 JAN 2011

ISBN Information

Print ISBN: 9783527326310

Online ISBN: 9783527633104

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Keywords:

  • platinum-based anticancer drugs;
  • cisplatin mechanism;
  • current platinum-based compound limitation;
  • platinum antitumor drug development

Summary

This chapter contains sections titled:

  • Introduction

  • Mechanism of Action of Cisplatin

  • Limitations of Current Platinum-Based Compounds: New Strategies

  • Novel Concepts in the Development of Platinum Antitumor Drugs

  • Concluding Remarks