4. New Trends and Future Developments of Platinum-Based Antitumor Drugs

  1. Prof. Dr. Enzo Alessio
  1. Xiaoyong Wang1 and
  2. Zijian Guo2

Published Online: 23 FEB 2011

DOI: 10.1002/9783527633104.ch4

Bioinorganic Medicinal Chemistry

Bioinorganic Medicinal Chemistry

How to Cite

Wang, X. and Guo, Z. (2011) New Trends and Future Developments of Platinum-Based Antitumor Drugs, in Bioinorganic Medicinal Chemistry (ed E. Alessio), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527633104.ch4

Editor Information

  1. University of Trieste, Department of Chemical Sciences, Via Giorgieri 1, 34127 Trieste, Italy

Author Information

  1. 1

    Nanjing University, School of Life Sciences, State Key Laboratory of Pharmaceutical Biotechnology, Nanjing 210093, P.R. China

  2. 2

    Nanjing University, School of Chemistry and Chemical Engineering, State Key Laboratory of Coordination Chemistry, Nanjing 210093, P.R. China

Publication History

  1. Published Online: 23 FEB 2011
  2. Published Print: 26 JAN 2011

ISBN Information

Print ISBN: 9783527326310

Online ISBN: 9783527633104



  • platinum-based antitumor drugs;
  • mechanism of action;
  • mechanism of resistance;
  • monofunctional platinum(II) complexes;
  • trans-platinum(II) complexes;
  • multinuclear platinum(II) complexes;
  • platinum(IV) complexes;
  • platinum drug delivery


This chapter contains sections titled:

  • Introduction

  • Mechanisms of Action and Resistance

  • Monofunctional Platinum(II) Complexes

  • Trans-Platinum(II) Complexes

  • Multinuclear Platinum(II) Complexes

  • Platinum(IV) Complexes

  • Delivery of Platinum Drugs

  • Concluding Remarks and Future Perspectives