1. From Milligrams to Tons: The Importance of Synthesis and Process Research in the Development of New Drugs

  1. Prof. Dr. Takayuki Shioiri2,
  2. Dr. Kunisuke Izawa3 and
  3. Dr. Toshiro Konoike4
  1. Martin Karpf

Published Online: 5 OCT 2010

DOI: 10.1002/9783527633678.ch1

Pharmaceutical Process Chemistry

Pharmaceutical Process Chemistry

How to Cite

Karpf, M. (2010) From Milligrams to Tons: The Importance of Synthesis and Process Research in the Development of New Drugs, in Pharmaceutical Process Chemistry (eds T. Shioiri, K. Izawa and T. Konoike), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527633678.ch1

Editor Information

  1. 2

    1-18-12 Minamigaoka, Nisshin, Aichi 470-0114, Japan

  2. 3

    Intermediate Chemicals Dept., Ajinomoto Co., Inc., 1-15-1 Kyobashi, Chuo-ku, Tokyo 104-8315, Japan

  3. 4

    CMC Development Laboratories, Shionogi & Co., Ltd., 1-3 Kuise Terajima 2-chome, Amagasaki, Hyogo 660-0813, Japan

Author Information

  1. F. Hoffmann-La Roche Ltd, Synthesis and Process Research, pRED, Therapeutic Modalities, Grenzacherstrasse 124, 4070 Basel, Switzerland

Publication History

  1. Published Online: 5 OCT 2010
  2. Published Print: 27 OCT 2010

ISBN Information

Print ISBN: 9783527326501

Online ISBN: 9783527633678

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Keywords:

  • synthesis and process research;
  • Lazabemide;
  • tetrahydrolipstatin;
  • Saquinavir;
  • oseltamivir phosphate;
  • discovery chemistry;
  • Tamiflu;
  • process chemistry

Summary

This chapter contains sections titled:

  • Introduction

  • The Synthetic Development of the Monoamine Oxidase-B Inhibitor Lazabemide™

  • The Synthetic Development of the Lipase Inhibitor Tetrahydrolipstatin (Xenical™)

  • The Synthetic Development of the HIV Protease Inhibitor Saquinavir (Invirase™)

  • The Synthetic Development of the Influenza Neuraminidase Inhibitor Oseltamivir Phosphate (Tamiflu™)

  • References