10. Process Development of Amrubicin Hydrochloride, an Anthracycline Anticancer Drug

  1. Prof. Dr. Takayuki Shioiri3,
  2. Dr. Kunisuke Izawa4 and
  3. Dr. Toshiro Konoike5
  1. Kazuhiko Takahashi1 and
  2. Mitsuharu Hanada2

Published Online: 5 OCT 2010

DOI: 10.1002/9783527633678.ch10

Pharmaceutical Process Chemistry

Pharmaceutical Process Chemistry

How to Cite

Takahashi, K. and Hanada, M. (2010) Process Development of Amrubicin Hydrochloride, an Anthracycline Anticancer Drug, in Pharmaceutical Process Chemistry (eds T. Shioiri, K. Izawa and T. Konoike), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527633678.ch10

Editor Information

  1. 3

    1-18-12 Minamigaoka, Nisshin, Aichi 470-0114, Japan

  2. 4

    Intermediate Chemicals Dept., Ajinomoto Co., Inc., 1-15-1 Kyobashi, Chuo-ku, Tokyo 104-8315, Japan

  3. 5

    CMC Development Laboratories, Shionogi & Co., Ltd., 1-3 Kuise Terajima 2-chome, Amagasaki, Hyogo 660-0813, Japan

Author Information

  1. 1

    Process Chemistry R&D Labs, Dainippon Sumitomo, Pharma Co., Ltd., 1-5-51 Ebie, Fukushima-ku, Osaka 553-0001, Japan

  2. 2

    Pharmacology Research Labs, Dainippon Sumitomo, Pharma Co., Ltd., 3-1-98 Kasugade-naka, Konohana-Ku, Osaka 554-0022, Japan

Publication History

  1. Published Online: 5 OCT 2010
  2. Published Print: 27 OCT 2010

ISBN Information

Print ISBN: 9783527326501

Online ISBN: 9783527633678

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Keywords:

  • amrubicin hydrochloride;
  • DMSO-sodium hydride method;
  • anthracycline anticancer drug;
  • DDH;
  • AIBN;
  • ARC;
  • polymorphism;
  • drying method

Summary

This chapter contains sections titled:

  • Introduction

  • Original Synthetic Route for Amrubicin

  • Amrubicin Bulk Production Synthetic Method

  • Conclusion

  • References