12. An Efficient Synthesis of the Protein Kinase Cβ Inhibitor JTT-010

  1. Prof. Dr. Takayuki Shioiri2,
  2. Dr. Kunisuke Izawa3 and
  3. Dr. Toshiro Konoike4
  1. Takashi Inaba

Published Online: 5 OCT 2010

DOI: 10.1002/9783527633678.ch12

Pharmaceutical Process Chemistry

Pharmaceutical Process Chemistry

How to Cite

Inaba, T. (2010) An Efficient Synthesis of the Protein Kinase Cβ Inhibitor JTT-010, in Pharmaceutical Process Chemistry (eds T. Shioiri, K. Izawa and T. Konoike), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527633678.ch12

Editor Information

  1. 2

    1-18-12 Minamigaoka, Nisshin, Aichi 470-0114, Japan

  2. 3

    Intermediate Chemicals Dept., Ajinomoto Co., Inc., 1-15-1 Kyobashi, Chuo-ku, Tokyo 104-8315, Japan

  3. 4

    CMC Development Laboratories, Shionogi & Co., Ltd., 1-3 Kuise Terajima 2-chome, Amagasaki, Hyogo 660-0813, Japan

Author Information

  1. Central Pharmaceutical, Research Institute, Japan Tobacco Inc., 1-1 Murasaki-cho, Takatsuki, Osaka 569-1125, Japan

Publication History

  1. Published Online: 5 OCT 2010
  2. Published Print: 27 OCT 2010

ISBN Information

Print ISBN: 9783527326501

Online ISBN: 9783527633678

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Keywords:

  • PKCβ inhibitor;
  • JTT-010;
  • efficient synthesis;
  • indole-fused pyrrolidine;
  • formal [3 + 2] cycloaddition;
  • cyclopropane

Summary

This chapter contains sections titled:

  • Introduction

  • Synthetic Strategies

  • Key Intermediate Synthesis

  • Replacement of the Hydroxyl Group of 1 with an Amino Group

  • Construction of JTT-010

  • Conclusion

  • References