13. Process Development of Oral Carbapenem Tebipenem Pivoxil, TBPM-PI

  1. Prof. Dr. Takayuki Shioiri2,
  2. Dr. Kunisuke Izawa3 and
  3. Dr. Toshiro Konoike4
  1. Takao Abe and
  2. Masataka Kitamura

Published Online: 5 OCT 2010

DOI: 10.1002/9783527633678.ch13

Pharmaceutical Process Chemistry

Pharmaceutical Process Chemistry

How to Cite

Abe, T. and Kitamura, M. (2010) Process Development of Oral Carbapenem Tebipenem Pivoxil, TBPM-PI, in Pharmaceutical Process Chemistry (eds T. Shioiri, K. Izawa and T. Konoike), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527633678.ch13

Editor Information

  1. 2

    1-18-12 Minamigaoka, Nisshin, Aichi 470-0114, Japan

  2. 3

    Intermediate Chemicals Dept., Ajinomoto Co., Inc., 1-15-1 Kyobashi, Chuo-ku, Tokyo 104-8315, Japan

  3. 4

    CMC Development Laboratories, Shionogi & Co., Ltd., 1-3 Kuise Terajima 2-chome, Amagasaki, Hyogo 660-0813, Japan

Author Information

  1. Medicinal Chemistry, Research Laboratory, CMC Research Laboratories, Pharmaceutical Research Center, Meiji Seika Kaisha, Ltd., 760 Morooka-cho, Yokohama 222-8567, Japan

Publication History

  1. Published Online: 5 OCT 2010
  2. Published Print: 27 OCT 2010

ISBN Information

Print ISBN: 9783527326501

Online ISBN: 9783527633678

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Keywords:

  • oral carbapenem;
  • orapenem;
  • tebipenem pivoxil;
  • TBPM-PI;
  • TBPM;
  • TAT

Summary

This chapter contains sections titled:

  • Introduction

  • Discovery of TBPM-PI

  • Synthetic Process of Side Chain on the C2-Position of TBPM, TAT

  • Synthetic Process of TBPM-PI from 4-Nitrobenzyl (1R,5R,6S)-2- diphenylphosphoryloxy-6-[(R)-1-hydroxyethyl]-1-methyl-1-carbapen-2-em-3-carboxylate, MAP

  • Summary and Outlook

  • Acknowledgments

  • References