15. The Use of Continuous Processing to Make AZD 4407 Intermediates

  1. Prof. Dr. Takayuki Shioiri2,
  2. Dr. Kunisuke Izawa3 and
  3. Dr. Toshiro Konoike4
  1. Andrew S. Wells

Published Online: 5 OCT 2010

DOI: 10.1002/9783527633678.ch15

Pharmaceutical Process Chemistry

Pharmaceutical Process Chemistry

How to Cite

Wells, A. S. (2010) The Use of Continuous Processing to Make AZD 4407 Intermediates, in Pharmaceutical Process Chemistry (eds T. Shioiri, K. Izawa and T. Konoike), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527633678.ch15

Editor Information

  1. 2

    1-18-12 Minamigaoka, Nisshin, Aichi 470-0114, Japan

  2. 3

    Intermediate Chemicals Dept., Ajinomoto Co., Inc., 1-15-1 Kyobashi, Chuo-ku, Tokyo 104-8315, Japan

  3. 4

    CMC Development Laboratories, Shionogi & Co., Ltd., 1-3 Kuise Terajima 2-chome, Amagasaki, Hyogo 660-0813, Japan

Author Information

  1. AstraZeneca, Global Process R&D, 42/2/2.0 Bakewell Road, Loughborough, Leicestershire LE11 5RH, United Kingdom

Publication History

  1. Published Online: 5 OCT 2010
  2. Published Print: 27 OCT 2010

ISBN Information

Print ISBN: 9783527326501

Online ISBN: 9783527633678

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Keywords:

  • AZD 4407;
  • microreactor;
  • flow chemistry;
  • lithiation;
  • disulfide synthesis;
  • exothermic reaction

Summary

This chapter contains sections titled:

  • Green Chemistry and the Drive for Sustainability

  • Advantages of Chemistry in Continuous-Flow Reactors

  • Introduction to AZD 4407

  • Comparison of the Synthetic Routes Used to Prepare AZD 4407

  • Conversion of Batch to a Flow Process

  • Conclusions

  • Acknowledgments

  • References