17. Development of a Novel Synthetic Method for RNA Oligomers

  1. Prof. Dr. Takayuki Shioiri2,
  2. Dr. Kunisuke Izawa3 and
  3. Dr. Toshiro Konoike4
  1. Tadaaki Ohgi and
  2. Junichi Yano

Published Online: 5 OCT 2010

DOI: 10.1002/9783527633678.ch17

Pharmaceutical Process Chemistry

Pharmaceutical Process Chemistry

How to Cite

Ohgi, T. and Yano, J. (2010) Development of a Novel Synthetic Method for RNA Oligomers, in Pharmaceutical Process Chemistry (eds T. Shioiri, K. Izawa and T. Konoike), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527633678.ch17

Editor Information

  1. 2

    1-18-12 Minamigaoka, Nisshin, Aichi 470-0114, Japan

  2. 3

    Intermediate Chemicals Dept., Ajinomoto Co., Inc., 1-15-1 Kyobashi, Chuo-ku, Tokyo 104-8315, Japan

  3. 4

    CMC Development Laboratories, Shionogi & Co., Ltd., 1-3 Kuise Terajima 2-chome, Amagasaki, Hyogo 660-0813, Japan

Author Information

  1. Nippon Shinyaku Co., Ltd, Discovery Research Laboratories, 3-14-1 Sakura, Tsukuba City, Ibaraki 305-0003, Japan

Publication History

  1. Published Online: 5 OCT 2010
  2. Published Print: 27 OCT 2010

ISBN Information

Print ISBN: 9783527326501

Online ISBN: 9783527633678

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Keywords:

  • RNA oligomers;
  • CEM amidites;
  • TBDMS;
  • TBAF;
  • 2-cyanoethoxymethyl

Summary

This chapter contains sections titled:

  • Introduction

  • Synthesis of CEM Amidites

  • Synthesis of RNA Oligomers from CEM Amidites

  • Acknowledgments

  • References