19. Scientific Strategy for Optical Resolution by Salt Crystallization: New Methodologies for Controlling Crystal Shape, Crystallization, and Chirality of Diastereomeric Salt

  1. Prof. Dr. Takayuki Shioiri3,
  2. Dr. Kunisuke Izawa4 and
  3. Dr. Toshiro Konoike5
  1. Rumiko Sakurai1 and
  2. Kenichi Sakai2

Published Online: 5 OCT 2010

DOI: 10.1002/9783527633678.ch19

Pharmaceutical Process Chemistry

Pharmaceutical Process Chemistry

How to Cite

Sakurai, R. and Sakai, K. (2010) Scientific Strategy for Optical Resolution by Salt Crystallization: New Methodologies for Controlling Crystal Shape, Crystallization, and Chirality of Diastereomeric Salt, in Pharmaceutical Process Chemistry (eds T. Shioiri, K. Izawa and T. Konoike), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527633678.ch19

Editor Information

  1. 3

    1-18-12 Minamigaoka, Nisshin, Aichi 470-0114, Japan

  2. 4

    Intermediate Chemicals Dept., Ajinomoto Co., Inc., 1-15-1 Kyobashi, Chuo-ku, Tokyo 104-8315, Japan

  3. 5

    CMC Development Laboratories, Shionogi & Co., Ltd., 1-3 Kuise Terajima 2-chome, Amagasaki, Hyogo 660-0813, Japan

Author Information

  1. 1

    Iwaki Meisei University, Faculty of Pharmacy, Iwaki, Fukushima 970-8044, Japan

  2. 2

    Toray Fine Chemicals Co. Ltd., Technology Development Division, Nagoya, Aichi 455-8502, Japan

Publication History

  1. Published Online: 5 OCT 2010
  2. Published Print: 27 OCT 2010

ISBN Information

Print ISBN: 9783527326501

Online ISBN: 9783527633678

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Keywords:

  • resolution via crystallization;
  • diastereomeric salt;
  • concept of space filler;
  • crystal habit modification;
  • DCR

Summary

This chapter contains sections titled:

  • Introduction

  • Control of Crystal Shape: Crystal Habit Modification

  • Control of Crystallization: Concept of Space Filler

  • Control of Chirality: Dielectrically Controlled Optical Resolution (DCR)

  • Conclusion and Prospect

  • References