6. Direct Reductive Amination with Amine Boranes

  1. Prof. Dr. Takayuki Shioiri2,
  2. Dr. Kunisuke Izawa3 and
  3. Dr. Toshiro Konoike4
  1. Karl Matos and
  2. Elizabeth R. Burkhardt

Published Online: 5 OCT 2010

DOI: 10.1002/9783527633678.ch6

Pharmaceutical Process Chemistry

Pharmaceutical Process Chemistry

How to Cite

Matos, K. and Burkhardt, E. R. (2010) Direct Reductive Amination with Amine Boranes, in Pharmaceutical Process Chemistry (eds T. Shioiri, K. Izawa and T. Konoike), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527633678.ch6

Editor Information

  1. 2

    1-18-12 Minamigaoka, Nisshin, Aichi 470-0114, Japan

  2. 3

    Intermediate Chemicals Dept., Ajinomoto Co., Inc., 1-15-1 Kyobashi, Chuo-ku, Tokyo 104-8315, Japan

  3. 4

    CMC Development Laboratories, Shionogi & Co., Ltd., 1-3 Kuise Terajima 2-chome, Amagasaki, Hyogo 660-0813, Japan

Author Information

  1. BASF Corporation, 1424 Mars-Evans City Road, Evans City, PA 16033, USA

Publication History

  1. Published Online: 5 OCT 2010
  2. Published Print: 27 OCT 2010

ISBN Information

Print ISBN: 9783527326501

Online ISBN: 9783527633678

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Keywords:

  • reductive amination;
  • amine borane;
  • stereoselective amination;
  • TBAB;
  • DMAB;
  • PEMB

Summary

This chapter contains sections titled:

  • Introduction

  • Types of Amine Boranes

  • Comparison to Sodium Triacetoxyborohydride (STAB)

  • Primary Amine Synthesis

  • Stereoselective Reductive Amination

  • Reaction Solvents

  • Reaction Workup

  • Conclusion

  • References