10. The Insulin/IGF-1 System in Neurodegeneration and Neurovascular Disease

  1. Prof. Dr. Achille G. Gravanis2 and
  2. Prof. Dr. Synthia H. Mellon3
  1. Przemyslaw (Mike) Sapieha and
  2. Lois Smith

Published Online: 2 FEB 2011

DOI: 10.1002/9783527633968.ch10

Hormones in Neurodegeneration, Neuroprotection, and Neurogenesis

Hormones in Neurodegeneration, Neuroprotection, and Neurogenesis

How to Cite

Sapieha, P. and Smith, L. (2011) The Insulin/IGF-1 System in Neurodegeneration and Neurovascular Disease, in Hormones in Neurodegeneration, Neuroprotection, and Neurogenesis (eds A. G. Gravanis and S. H. Mellon), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527633968.ch10

Editor Information

  1. 2

    University of Crete, Department of Pharmacology, School of Medicine, Stavrakia, 71110 Heraklion, Greece

  2. 3

    University of California, Department of Obstetrics, Gynecology, and Reproductive Sciences, The Center for Reproductive Sciences, 513 Parnassus Avenue, San Francisco, CA 94143, USA

Author Information

  1. Harvard Medical School, Department of Ophthalmology, 300 Longwood Avenue, Boston, MA, USA

Publication History

  1. Published Online: 2 FEB 2011
  2. Published Print: 14 JAN 2011

ISBN Information

Print ISBN: 9783527326273

Online ISBN: 9783527633968

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Keywords:

  • insulin;
  • IGF;
  • IGF signaling pathway;
  • neuroprotection;
  • neurovascular degeneration;
  • Alzheimer's disease

Summary

This chapter contains sections titled:

  • Introduction

  • Insulin and Insulin Growth Factors

  • Local versus Systemic Actions

  • Insulin/IGF Signaling Pathway

  • The Insulin/IGF Axis in the Brain

  • Insulin/IGF and Neuroprotection

  • Alzheimer's Disease

  • Parkinson's Disease

  • Vascular Dementia

  • Neurovascular Degeneration

  • Conclusion

  • References