19. Human Neural Progenitor Cells: Mitotic and Neurogenic Effects of Growth Factors, Neurosteroids, and Excitatory Amino Acids

  1. Prof. Dr. Achille G. Gravanis4 and
  2. Prof. Dr. Synthia H. Mellon5
  1. Masatoshi Suzuki1,
  2. Jacalyn McHugh2 and
  3. Narisorn Kitiyanant3

Published Online: 2 FEB 2011

DOI: 10.1002/9783527633968.ch19

Hormones in Neurodegeneration, Neuroprotection, and Neurogenesis

Hormones in Neurodegeneration, Neuroprotection, and Neurogenesis

How to Cite

Suzuki, M., McHugh, J. and Kitiyanant, N. (2011) Human Neural Progenitor Cells: Mitotic and Neurogenic Effects of Growth Factors, Neurosteroids, and Excitatory Amino Acids, in Hormones in Neurodegeneration, Neuroprotection, and Neurogenesis (eds A. G. Gravanis and S. H. Mellon), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527633968.ch19

Editor Information

  1. 4

    University of Crete, Department of Pharmacology, School of Medicine, Stavrakia, 71110 Heraklion, Greece

  2. 5

    University of California, Department of Obstetrics, Gynecology, and Reproductive Sciences, The Center for Reproductive Sciences, 513 Parnassus Avenue, San Francisco, CA 94143, USA

Author Information

  1. 1

    University of Wisconsin Madison, Department of Comparative Biosciences, School of Veterinary Medicine, 2015 Linden Dr. Madison, WI 53706, USA

  2. 2

    The Cedars-Sinai Regenerative, Medicine Institute, 8700 Beverly Blvd., Los Angeles, CA 90048, USA

  3. 3

    Mahidol University, Institute of Molecular Biosciences, Phutthamonthon 4 Rd, Nakhonpathom 73170, Thailand

Publication History

  1. Published Online: 2 FEB 2011
  2. Published Print: 14 JAN 2011

ISBN Information

Print ISBN: 9783527326273

Online ISBN: 9783527633968

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Keywords:

  • DHEA;
  • stem cell;
  • neural progenitor cell;
  • neurosteroid;
  • neurogenesis;
  • glutamate

Summary

This chapter contains sections titled:

  • Introduction

  • Neural Stem/Progenitor Cells as a Model of Human Cortical Development

  • Mitotic and Neurogenic Effects of a Neurosteroid: Dehydroepiandrosterone (DHEA)

  • Glutamate Enhances Proliferation and Neurogenesis in hNPCs

  • Increased Neurogenic “Radial Glial”-like Cells within Human Neurosphere Cultures

  • Conclusions

  • Acknowledgments

  • References