4. Endogenous and Synthetic Neurosteroids in the Treatment of Niemann–Pick Type C Disease

  1. Prof. Dr. Achille G. Gravanis1 and
  2. Prof. Dr. Synthia H. Mellon2
  1. Prof. Dr. Synthia H. Mellon,
  2. Wenhui Gong and
  3. Marcus D. Schonemann

Published Online: 2 FEB 2011

DOI: 10.1002/9783527633968.ch4

Hormones in Neurodegeneration, Neuroprotection, and Neurogenesis

Hormones in Neurodegeneration, Neuroprotection, and Neurogenesis

How to Cite

Mellon, S. H., Gong, W. and Schonemann, M. D. (2011) Endogenous and Synthetic Neurosteroids in the Treatment of Niemann–Pick Type C Disease, in Hormones in Neurodegeneration, Neuroprotection, and Neurogenesis (eds A. G. Gravanis and S. H. Mellon), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527633968.ch4

Editor Information

  1. 1

    University of Crete, Department of Pharmacology, School of Medicine, Stavrakia, 71110 Heraklion, Greece

  2. 2

    University of California, Department of Obstetrics, Gynecology, and Reproductive Sciences, The Center for Reproductive Sciences, 513 Parnassus Avenue, San Francisco, CA 94143, USA

Author Information

  1. University of California, Department of Obstetrics, Gynecology, and Reproductive Sciences, The Center for Reproductive Sciences, 513 Parnassus Avenue, San Francisco, CA 94143, USA

Publication History

  1. Published Online: 2 FEB 2011
  2. Published Print: 14 JAN 2011

ISBN Information

Print ISBN: 9783527326273

Online ISBN: 9783527633968

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Keywords:

  • allopregnanolone;
  • Niemann–Pick type C;
  • GABAA receptor;
  • pregnane-X-receptor

Summary

This chapter contains sections titled:

  • Introduction

  • Niemann–Pick Type C Disease as a Model of Disrupted Neurosteroidogenesis

  • Steroidogenesis and Neurosteroidogenesis in NP-C

  • Treatment of NP-C Mice with Allopregnanolone

  • Mechanism of Allopregnanolone Action: GABAA Receptor

  • Mechanism of Allopregnanolone Action: Pregnane-X Receptor

  • Mechanism of Allopregnanolone Action: Reduction of Cellular Oxidative Stress

  • Conclusions – Mechanisms of Allopregnanolone Action in Treatment of NP-C and Other Neurodegenerative Diseases

  • Acknowledgments

  • References