6. Regulation of Structural Plasticity and Neurogenesis during Stress and Diabetes; Protective Effects of Glucocorticoid Receptor Antagonists

  1. Prof. Dr. Achille G. Gravanis3 and
  2. Prof. Dr. Synthia H. Mellon4
  1. Paul J. Lucassen1,
  2. Carlos P. Fitzsimons1,
  3. Erno Vreugdenhil2,
  4. Pu Hu1,
  5. Charlotte Oomen1,
  6. Yanina Revsin2,
  7. Marian Joëls1 and
  8. Edo Ronald de Kloet2

Published Online: 2 FEB 2011

DOI: 10.1002/9783527633968.ch6

Hormones in Neurodegeneration, Neuroprotection, and Neurogenesis

Hormones in Neurodegeneration, Neuroprotection, and Neurogenesis

How to Cite

Lucassen, P. J., Fitzsimons, C. P., Vreugdenhil, E., Hu, P., Oomen, C., Revsin, Y., Joëls, M. and de Kloet, E. R. (2011) Regulation of Structural Plasticity and Neurogenesis during Stress and Diabetes; Protective Effects of Glucocorticoid Receptor Antagonists, in Hormones in Neurodegeneration, Neuroprotection, and Neurogenesis (eds A. G. Gravanis and S. H. Mellon), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527633968.ch6

Editor Information

  1. 3

    University of Crete, Department of Pharmacology, School of Medicine, Stavrakia, 71110 Heraklion, Greece

  2. 4

    University of California, Department of Obstetrics, Gynecology, and Reproductive Sciences, The Center for Reproductive Sciences, 513 Parnassus Avenue, San Francisco, CA 94143, USA

Author Information

  1. 1

    University of Amsterdam, Centre for Neuroscience, Swammerdam Institute of Life, Sciences, Science Park 904, 1098 XH, Amsterdam, The Netherlands

  2. 2

    Leiden University, Division of Medical Pharmacology, Leiden Amsterdam Center for Drug Research, Einsteinweg 55, 2300RA Leiden, The Netherlands

Publication History

  1. Published Online: 2 FEB 2011
  2. Published Print: 14 JAN 2011

ISBN Information

Print ISBN: 9783527326273

Online ISBN: 9783527633968

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Keywords:

  • adult neurogenesis;
  • stress;
  • glucocorticoid;
  • depression;
  • diabetes;
  • mifepristone;
  • hippocampus

Summary

This chapter contains sections titled:

  • The Stress Response

  • HPA Axis and Glucocorticoids

  • Glucocorticoid Actions

  • Feedback Regulation

  • Stress and Depression

  • Stress-Induced Viability Changes in the Hippocampus: Effect on Function, Volume, Cell Number, and Apoptosis

  • Effects of Stress on Dendritic Atrophy, Spine, and Synaptic Changes

  • Adult Hippocampal Neurogenesis

  • Effect of Stress on Adult Hippocampal Neurogenesis

  • Normalization of the Effects of Stress on the Hippocampus by Means of GR Blockade

  • Normalization of Hippocampal Alterations during Diabetes Mellitus Using the GR Antagonist Mifepristone

  • Concluding Remarks

  • Acknowledgments

  • Disclosure

  • References