6. Antibody-Directed Enzyme Prodrug Therapy (ADEPT) - Basic Principles and its Practice So Far

  1. Dr. Felix Kratz2,
  2. Dr. Peter Senter PhD3 and
  3. Dr. Henning Steinhagen4
  1. Kenneth D. Bagshawe

Published Online: 16 DEC 2011

DOI: 10.1002/9783527634057.ch6

Drug Delivery in Oncology: From Basic Research to Cancer Therapy

Drug Delivery in Oncology: From Basic Research to Cancer Therapy

How to Cite

Bagshawe, K. D. (2011) Antibody-Directed Enzyme Prodrug Therapy (ADEPT) - Basic Principles and its Practice So Far, in Drug Delivery in Oncology: From Basic Research to Cancer Therapy (eds F. Kratz, P. Senter and H. Steinhagen), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527634057.ch6

Editor Information

  1. 2

    Division of Macromolecular Prodrugs, Tumor Biology Center, Breisacherstrasse 117, D-79106 Freiburg, Germany

  2. 3

    Seattle Genetics, Inc., 218, Drive S.E. Bothell, Seattle, WA 98021, USA

  3. 4

    Grünenthal GmbH, Zieglerstr. 6, 52078 Aachen, Germany

Author Information

  1. Imperial College London, UK

Publication History

  1. Published Online: 16 DEC 2011
  2. Published Print: 19 OCT 2011

ISBN Information

Print ISBN: 9783527328239

Online ISBN: 9783527634057

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Keywords:

  • ADEPT;
  • enzyme;
  • prodrug;
  • antibody;
  • cancer

Summary

This chapter contains sections titled:

  • Introduction

  • Principles and the Components of ADEPT

  • Third Essential

  • ADEPT Studies Elsewhere

  • Reagents for First Clinical Trials in London (1990-1995)

  • Technology Advances

  • ADEPT Future

  • References