15. What Have “Omics” Taught Us about the Health Risks Associated with Exposure to Low Doses of Ionizing Radiation

  1. Prof. Dr. Günter Obe2,3,
  2. Dr. Burkhard Jandrig4,
  3. Prof. Dr. Gary E. Marchant5,
  4. Dipl. Päd. Holger Schütz6,
  5. Prof. Dr. Peter M. Wiedemann7
  1. William F. Morgan,
  2. Marianne B. Sowa

Published Online: 27 APR 2011

DOI: 10.1002/9783527634613.ch15

Book Title

Cancer Risk Evaluation: Methods and Trends

Cancer Risk Evaluation: Methods and Trends

Additional Information

How to Cite

Morgan, W. F. and Sowa, M. B. (2011) What Have “Omics” Taught Us about the Health Risks Associated with Exposure to Low Doses of Ionizing Radiation, in Cancer Risk Evaluation: Methods and Trends (eds G. Obe, B. Jandrig, G. E. Marchant, H. Schütz and P. M. Wiedemann), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527634613.ch15

Editor Information

  1. 2

    Ret. from University Duisburg-Essen, Germany

  2. 3

    Gershwinstrasse 33, 14513 Teltow, Germany

  3. 4

    Max-Delbrück-Center for Molecular Medicine (MDC), Robert-Rössle-Str. 10, 13125 Berlin, Germany

  4. 5

    Arizona State University, Sandra Day O'Connor College of Law, P.O. Box 877906, Tempe, AZ 85287-796, USA

  5. 6

    Research Center Jülich, Institute of Neuroscience and Medicine (INM-8), 52425 Jülich, Germany

  6. 7

    Karlsruher Institut für Technologie (KIT), TAB – Büro für Technikfolgen-Abschätzung beim Deutschen Bundestag, Neue Schönhauser Straße 10, 10178 Berlin, Germany

Author Information

  1. Pacific Northwest National Laboratory, Cell Biology and Biochemistry, P.O. Box 999, MSIN P7-56, Richland, WA 99354, USA

Publication History

  1. Published Online: 27 APR 2011
  2. Published Print: 20 APR 2011

ISBN Information

Print ISBN: 9783527327539

Online ISBN: 9783527634613

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CHAPTER TOOLS

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Keywords:

  • adaptive responses;
  • bystander effect;
  • DNA damage;
  • gene expression patterns;
  • ionizing radiation;
  • mitogen-activated protein kinase;
  • signaling cascades

Summary

This chapter contains sections titled:

  • Introduction

  • Pre-“Omics”

  • Functional Genomics

  • Gene Expression Profiling for Nontargeted Effects Induced by Exposure to Ionizing Radiation

  • Gene Expression Profiling for Adaptive Responses Induced by Exposure to Ionizing Radiation

  • In Vivo Gene Profiling after Irradiation

  • Radiation-Induced Oscillatory Signaling

  • Proteomic Profiling after Exposure to Ionizing Radiation

  • Metabolomic Profiling after Exposure to Ionizing Radiation

  • Conclusions

  • References

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