2. Models of Cancer Development: Genetic and Environmental Influences

  1. Prof. Dr. Günter Obe1,2,
  2. Dr. Burkhard Jandrig3,
  3. Prof. Dr. Gary E. Marchant4,
  4. Dipl. Päd. Holger Schütz5 and
  5. Prof. Dr. Peter M. Wiedemann6
  1. Dr. Burkhard Jandrig

Published Online: 27 APR 2011

DOI: 10.1002/9783527634613.ch2

Cancer Risk Evaluation: Methods and Trends

Cancer Risk Evaluation: Methods and Trends

How to Cite

Jandrig, B. (2011) Models of Cancer Development: Genetic and Environmental Influences, in Cancer Risk Evaluation: Methods and Trends (eds G. Obe, B. Jandrig, G. E. Marchant, H. Schütz and P. M. Wiedemann), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527634613.ch2

Editor Information

  1. 1

    Ret. from University Duisburg-Essen, Germany

  2. 2

    Gershwinstrasse 33, 14513 Teltow, Germany

  3. 3

    Max-Delbrück-Center for Molecular Medicine (MDC), Robert-Rössle-Str. 10, 13125 Berlin, Germany

  4. 4

    Arizona State University, Sandra Day O'Connor College of Law, P.O. Box 877906, Tempe, AZ 85287-796, USA

  5. 5

    Research Center Jülich, Institute of Neuroscience and Medicine (INM-8), 52425 Jülich, Germany

  6. 6

    Karlsruher Institut für Technologie (KIT), TAB – Büro für Technikfolgen-Abschätzung beim Deutschen Bundestag, Neue Schönhauser Straße 10, 10178 Berlin, Germany

Author Information

  1. Max-Delbrück-Center for Molecular Medicine (MDC), Robert-Rössle-Str. 10, 13125 Berlin, Germany

Publication History

  1. Published Online: 27 APR 2011
  2. Published Print: 20 APR 2011

ISBN Information

Print ISBN: 9783527327539

Online ISBN: 9783527634613

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Keywords:

  • cell proliferation;
  • oncogenes;
  • programmed cell death;
  • signal transduction;
  • tissue homeostasis;
  • tumor suppressor genes;
  • tumorigenesis

Summary

This chapter contains sections titled:

  • Introduction

  • Specific Characteristics of Tumors

  • Tumorigenesis as a Multistep Process

  • Epigenetic Changes in Cancer Development

  • miRNAs and Cancer

  • Cancer Stem Cells

  • Cancer and the Environment

  • Systems Analysis of Cancer

  • Outlook

  • References