3. Endogenous DNA Damage and Its Relevance for the Initiation of Carcinogenesis

  1. Prof. Dr. Günter Obe2,3,
  2. Dr. Burkhard Jandrig4,
  3. Prof. Dr. Gary E. Marchant5,
  4. Dipl. Päd. Holger Schütz6 and
  5. Prof. Dr. Peter M. Wiedemann7
  1. Bernd Epe and
  2. Markus Fußer

Published Online: 27 APR 2011

DOI: 10.1002/9783527634613.ch3

Cancer Risk Evaluation: Methods and Trends

Cancer Risk Evaluation: Methods and Trends

How to Cite

Epe, B. and Fußer, M. (2011) Endogenous DNA Damage and Its Relevance for the Initiation of Carcinogenesis, in Cancer Risk Evaluation: Methods and Trends (eds G. Obe, B. Jandrig, G. E. Marchant, H. Schütz and P. M. Wiedemann), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527634613.ch3

Editor Information

  1. 2

    Ret. from University Duisburg-Essen, Germany

  2. 3

    Gershwinstrasse 33, 14513 Teltow, Germany

  3. 4

    Max-Delbrück-Center for Molecular Medicine (MDC), Robert-Rössle-Str. 10, 13125 Berlin, Germany

  4. 5

    Arizona State University, Sandra Day O'Connor College of Law, P.O. Box 877906, Tempe, AZ 85287-796, USA

  5. 6

    Research Center Jülich, Institute of Neuroscience and Medicine (INM-8), 52425 Jülich, Germany

  6. 7

    Karlsruher Institut für Technologie (KIT), TAB – Büro für Technikfolgen-Abschätzung beim Deutschen Bundestag, Neue Schönhauser Straße 10, 10178 Berlin, Germany

Author Information

  1. University of Mainz, Institute of Pharmacy and Biochemistry, Staudingerweg 5, 55128 Mainz, Germany

Publication History

  1. Published Online: 27 APR 2011
  2. Published Print: 20 APR 2011

ISBN Information

Print ISBN: 9783527327539

Online ISBN: 9783527634613

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Keywords:

  • DNA damage;
  • misincorporation;
  • reactive oxygen species;
  • repair mechanisms;
  • single-strand breaks;
  • spontaneous hydrolysis

Summary

This chapter contains sections titled:

  • Introduction

  • Types and Generation of Oxidative DNA Modifications

  • Repair of Endogenous DNA Modifications

  • Basal Steady-State Levels

  • Contribution of Endogenous DNA Modifications to Cancer Risk

  • References