5. Acyclic and Cyclic Nucleoside Phosphonates

  1. Prof. Dr. Erik De Clercq
  1. Richard L. Mackman and
  2. Tomas Cihlar

Published Online: 12 MAY 2011

DOI: 10.1002/9783527635955.ch5

Antiviral Drug Strategies

Antiviral Drug Strategies

How to Cite

Mackman, R. L. and Cihlar, T. (2011) Acyclic and Cyclic Nucleoside Phosphonates, in Antiviral Drug Strategies (ed E. De Clercq), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527635955.ch5

Editor Information

  1. Rega Institute Medical Research, University of Leuven, Minderbroedersstraat 10, 3000 Leuven, Belgium

Author Information

  1. Gilead Sciences, Inc., 333 Lakeside Drive, Foster City, CA 94404, USA

Publication History

  1. Published Online: 12 MAY 2011
  2. Published Print: 6 APR 2011

Book Series:

  1. Methods and Principles in Medicinal Chemistry

Book Series Editors:

  1. Prof. Dr. Raimund Mannhold3,
  2. Prof. Dr. Hugo Kubinyi4 and
  3. Prof. Dr. Gerd Folkers5

Series Editor Information

  1. 3

    Molecular Drug Research Group, Heinrich‐Heine‐Universität, Universitätsstrasse 1, 40225 Düsseldorf, Germany

  2. 4

    Donnersbergstrasse 9, 67256 Weisenheim am Sand, Germany

  3. 5

    Collegium Helveticum, STW/ETH Zurich, 8092 Zurich, Switzerland

ISBN Information

Print ISBN: 9783527326969

Online ISBN: 9783527635955

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Keywords:

  • nucleoside phosphonates;
  • bioisosteres;
  • prodrug;
  • HIV;
  • HBV;
  • HCV;
  • reverse transcriptase;
  • RNA polymerase

Summary

This chapter contains sections titled:

  • Introduction

  • Nucleoside Phosphonate Strategy for Antivirals

  • Acyclic Nucleoside Phosphonates

  • Cyclic Nucleoside Phosphonates

  • Prodrugs of Nucleoside Phosphonates

  • Clinical Applications of Antiviral Nucleoside Phosphonates

  • Conclusions

  • References