13. Translation of Motilin and Ghrelin Receptor Agonists into Drugs for Gastrointestinal Disorders

  1. Prof. Dr. Miguel Castanho and
  2. Prof. Dr. Nuno C. Santos
  1. Gareth J. Sanger1,
  2. John Broad1 and
  3. David H. Alpers2

Published Online: 17 OCT 2011

DOI: 10.1002/9783527636730.ch13

Peptide Drug Discovery and Development: Translational Research in Academia and Industry

Peptide Drug Discovery and Development: Translational Research in Academia and Industry

How to Cite

Sanger, G. J., Broad, J. and Alpers, D. H. (2011) Translation of Motilin and Ghrelin Receptor Agonists into Drugs for Gastrointestinal Disorders, in Peptide Drug Discovery and Development: Translational Research in Academia and Industry (eds M. Castanho and N. C. Santos), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527636730.ch13

Editor Information

  1. University of Lisbon, Institute of Biochemistry, Av. Egas Moniz, 1649-028 Lisboa, Portugal

Author Information

  1. 1

    Queen Mary, University of London, Barts & The London School of Medicine and Dentistry, Wingate, Institute of Neurogastroenterology, 26 Ashfield Street, E1 2AJ London, UK

  2. 2

    Washington University School of Medicine, Department of Internal Medicine, Box 8031, 660 S Euclid Ave, MO 63110 St Louis, USA

Publication History

  1. Published Online: 17 OCT 2011
  2. Published Print: 5 OCT 2011

ISBN Information

Print ISBN: 9783527328918

Online ISBN: 9783527636730

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Keywords:

  • motilin;
  • ghrelin;
  • drug discovery;
  • gastroparesis;
  • TZP-101;
  • GSK962040

Summary

This chapter contains sections titled:

  • Introduction

  • Motilin and Ghrelin Receptor Agonists Under Development

  • Translational Value of Preclinical Assays

  • Clinical Translation: Selecting the “Right” Patient Population

  • Clinical Development of Motilin and Ghrelin Receptor Agonists

  • Conclusions