7. Omiganan Pentahydrochloride: A Novel, Broad-Spectrum Antimicrobial Peptide for Topical Use

  1. Prof. Dr. Miguel Castanho and
  2. Prof. Dr. Nuno C. Santos
  1. Evelina Rubinchik and
  2. Dominique Dugourd

Published Online: 17 OCT 2011

DOI: 10.1002/9783527636730.ch7

Peptide Drug Discovery and Development: Translational Research in Academia and Industry

Peptide Drug Discovery and Development: Translational Research in Academia and Industry

How to Cite

Rubinchik, E. and Dugourd, D. (2011) Omiganan Pentahydrochloride: A Novel, Broad-Spectrum Antimicrobial Peptide for Topical Use, in Peptide Drug Discovery and Development: Translational Research in Academia and Industry (eds M. Castanho and N. C. Santos), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527636730.ch7

Editor Information

  1. University of Lisbon, Institute of Biochemistry, Av. Egas Moniz, 1649-028 Lisboa, Portugal

Author Information

  1. BioWest Therapeutics Inc., Suite 1320–885 West Georgia, Vancouver, BC, V6C 2G2, Canada

Publication History

  1. Published Online: 17 OCT 2011
  2. Published Print: 5 OCT 2011

ISBN Information

Print ISBN: 9783527328918

Online ISBN: 9783527636730

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Keywords:

  • antimicrobial peptide;
  • omiganan pentahydrochloride;
  • topical application;
  • fungicidal activity;
  • bacteriocidal activity;
  • catheter-related infection

Summary

This chapter contains sections titled:

  • Omiganan: A Novel Anti-Infective Agent for Topical Indications

  • Structure and Mechanism of Action

  • Spectrum of Activity

  • Preclinical Efficacy Studies

  • Preclinical Toxicology Studies

  • Clinical Studies

  • Conclusions