8. Turning Endogenous Peptides into New Analgesics: The Example of Kyotorphin Derivatives

  1. Prof. Dr. Miguel Castanho and
  2. Prof. Dr. Nuno C. Santos
  1. Marta M. B. Ribeiro,
  2. Isa D. Serrano and
  3. Sónia Sá Santos

Published Online: 17 OCT 2011

DOI: 10.1002/9783527636730.ch8

Peptide Drug Discovery and Development: Translational Research in Academia and Industry

Peptide Drug Discovery and Development: Translational Research in Academia and Industry

How to Cite

Ribeiro, M. M. B., Serrano, I. D. and Santos, S. S. (2011) Turning Endogenous Peptides into New Analgesics: The Example of Kyotorphin Derivatives, in Peptide Drug Discovery and Development: Translational Research in Academia and Industry (eds M. Castanho and N. C. Santos), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527636730.ch8

Editor Information

  1. University of Lisbon, Institute of Biochemistry, Av. Egas Moniz, 1649-028 Lisboa, Portugal

Author Information

  1. Universidade Lisboa, Instituto de Medicina Molecular, Faculdade de Medicina, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal

Publication History

  1. Published Online: 17 OCT 2011
  2. Published Print: 5 OCT 2011

ISBN Information

Print ISBN: 9783527328918

Online ISBN: 9783527636730

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Keywords:

  • kyotorphin;
  • kyotorphin derivatives;
  • analgesic drugs;
  • opioids;
  • blood–brain barrier crossing;
  • peptide–membrane interaction

Summary

This chapter contains sections titled:

  • Introduction

  • Peptides as Future Drug Candidates

  • Central Nervous System Analgesic Peptides

  • Endogenous Opioid System

  • Strategies to Deliver Analgesic Peptides to the Brain

  • Development of New Opioid-Derived Peptides

  • Kyotorphin – the Potential of an Endogenous Dipeptide

  • New KTP Derivatives

  • Assessing BBB Permeability with Peptide – Membrane Partition Studies

  • Kyotorphins: Partition to the Membrane and Enhanced Analgesic Activity

  • Academia and Pharmaceutical Industry: Friends or Foes?