9. The Development of Romiplostim – A Therapeutic Peptibody Used to Stimulate Platelet Production

  1. Prof. Dr. Miguel Castanho and
  2. Prof. Dr. Nuno C. Santos
  1. Graham Molineux and
  2. Ping Wei

Published Online: 17 OCT 2011

DOI: 10.1002/9783527636730.ch9

Peptide Drug Discovery and Development: Translational Research in Academia and Industry

Peptide Drug Discovery and Development: Translational Research in Academia and Industry

How to Cite

Molineux, G. and Wei, P. (2011) The Development of Romiplostim – A Therapeutic Peptibody Used to Stimulate Platelet Production, in Peptide Drug Discovery and Development: Translational Research in Academia and Industry (eds M. Castanho and N. C. Santos), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527636730.ch9

Editor Information

  1. University of Lisbon, Institute of Biochemistry, Av. Egas Moniz, 1649-028 Lisboa, Portugal

Author Information

  1. Amgen Inc, Hematology and Oncology Discovery Research, One Amgen Center Drive, Mailstop, 15-2-A, Thousand Oaks, CA 91320, USA

Publication History

  1. Published Online: 17 OCT 2011
  2. Published Print: 5 OCT 2011

ISBN Information

Print ISBN: 9783527328918

Online ISBN: 9783527636730

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Keywords:

  • romiplostim;
  • c-Mpl;
  • peptibody;
  • platelets;
  • immune thrombocytopenic purpura (ITP)

Summary

This chapter contains sections titled:

  • Introduction

  • Thrombopoietin and c-Mpl

  • Discovery and Optimization of Romiplostim

  • Pharmacodynamics (PD) and Pharmacokinetics (PK) of Romiplostim

  • A Brief ITP Primer

  • Romiplostim Clinical Data

  • Safety and Other Insights Gained from Romiplostim Design and Development