24. Biomimetic Thin Films as a QCM-D Sensor Platform to Detect Macromolecular Interactions

  1. Prof. Dr. Wolfgang Knoll3 and
  2. Prof. Dr. Rigoberto C. Advincula4
  1. Nam-Joon Cho1 and
  2. Curtis W. Frank2

Published Online: 7 JUN 2011

DOI: 10.1002/9783527638482.ch24

Functional Polymer Films: 2 Volume Set

Functional Polymer Films: 2 Volume Set

How to Cite

Cho, N.-J. and Frank, C. W. (2011) Biomimetic Thin Films as a QCM-D Sensor Platform to Detect Macromolecular Interactions, in Functional Polymer Films: 2 Volume Set (eds W. Knoll and R. C. Advincula), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527638482.ch24

Editor Information

  1. 3

    AIT Austrian Institute of Technology GmbH, Donau-City-Straße 1, 1220 Vienna, Austria

  2. 4

    University of Houston, Department of Chemistry, Department of Chemical and Biomolecular Engineering, 136 Fleming Bldg., Houston, TX 77204-5003, USA

Author Information

  1. 1

    Stanford University, Division of Gastroenterology, School of Medicine, CCSR Bldg. Rm3110, 269 Campus Dr., Stanford, CA 94305-5025, USA

  2. 2

    Stanford University, Department of Chemical Engineering, 381 North South Mall #113, Stauffer III, Stanford, CA 94305-5025, USA

Publication History

  1. Published Online: 7 JUN 2011
  2. Published Print: 20 APR 2011

ISBN Information

Print ISBN: 9783527321902

Online ISBN: 9783527638482



  • biomimetic thin films;
  • macromolecular interactions;
  • quartz crystal microbalance;
  • sensor platforms;
  • viscoelastic property changes


Biomimetic thin films have great utility as sensor platforms for biological studies. In particular, cell-membrane-mimicking thin films composed of phospholipids have helped to provide insight into a range of macromolecular recognition events associated with important biological processes. To detect these interactions, the quartz crystal microbalance with dissipation monitoring (QCM-D) technique possesses the unique ability to simultaneously probe in real time the mass and viscoelastic property changes of biomimetic thin films. In this chapter, we first discuss QCM-D measurement principles. Thereafter, we examine how the QCM-D sensor has been applied to characterize different biomimetic thin films over the course of their self-assembly and subsequent interactions with biological macromolecules. In summary, this chapter demonstrates the effectiveness and versatility of biomimetic thin films coupled to the QCM-D sensor platform for studying macromolecular interactions.