28. Self-Assembled Multifunctional Polymers for Biointerfaces

  1. Prof. Dr. Wolfgang Knoll2 and
  2. Prof. Dr. Rigoberto C. Advincula3
  1. Géraldine Coullerez,
  2. Ganna Gorodyska,
  3. Erik Reimhult,
  4. Marcus Textor and
  5. H. Michelle Grandin

Published Online: 7 JUN 2011

DOI: 10.1002/9783527638482.ch28

Functional Polymer Films: 2 Volume Set

Functional Polymer Films: 2 Volume Set

How to Cite

Coullerez, G., Gorodyska, G., Reimhult, E., Textor, M. and Grandin, H. M. (2011) Self-Assembled Multifunctional Polymers for Biointerfaces, in Functional Polymer Films: 2 Volume Set (eds W. Knoll and R. C. Advincula), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527638482.ch28

Editor Information

  1. 2

    AIT Austrian Institute of Technology GmbH, Donau-City-Straße 1, 1220 Vienna, Austria

  2. 3

    University of Houston, Department of Chemistry, Department of Chemical and Biomolecular Engineering, 136 Fleming Bldg., Houston, TX 77204-5003, USA

Author Information

  1. ETH Zurich, Department of Materials, Laboratory for Surface, Science and Technology, Wolfgang-Pauli-Strasse 10, 8093 Zurich, Switzerland

Publication History

  1. Published Online: 7 JUN 2011
  2. Published Print: 20 APR 2011

ISBN Information

Print ISBN: 9783527321902

Online ISBN: 9783527638482



  • biointerface;
  • polymers;
  • thin films;
  • self-assembly;
  • monolayer;
  • nonfouling;
  • poly(ethylene glycol);
  • bioresponsive;
  • bioactive;
  • surface chemistry;
  • patterning;
  • protein;
  • peptide;
  • carbohydrate;
  • cells;
  • bacteria;
  • biosensors;
  • bioassays


Surface modifications based on biochemical or biological principles are important tools for the fabrication of diagnostic sensors, biomedical implants, and targeted drug-delivery carriers. Preparing well-designed model biointerfaces is a crucial step toward gaining a deeper insight into the fundamental aspects of protein–surface and cell–surface interactions and to enhance the biological performance of materials and surfaces in biotechnological and biomedical applications. This chapter will provide a brief survey of strategies used to tailor biological response with a special emphasis on surface coatings resistant to fouling by proteins, cells, or micro-organisms, as well as on surface coatings capable of eliciting specific biomolecular interactions that can furthermore be combined with micropatterning techniques to engineer adhesive areas in a noninteractive background. After introducing the biointerfacial phenomena, emphasis will be put on practical methods, primarily reviewing recent progress from our group, that aim at controlling the relationship between surface properties and biological response. In particular, material surface chemistries that are capable of modulating protein adsorption and cell adhesion will be described.