25. CLC Bio Integrated Platform for Handling and Analysis of Tag Sequencing Data

  1. Dr. Matthias Harbers2,3 and
  2. Prof. Dr. Günter Kahl4,5,6
  1. Roald Forsberg,
  2. Søren Mønsted and
  3. Anne-Mette Hein

Published Online: 23 JAN 2012

DOI: 10.1002/9783527644582.ch25

Tag-Based Next Generation Sequencing

Tag-Based Next Generation Sequencing

How to Cite

Forsberg, R., Mønsted, S. and Hein, A.-M. (2011) CLC Bio Integrated Platform for Handling and Analysis of Tag Sequencing Data, in Tag-Based Next Generation Sequencing (eds M. Harbers and G. Kahl), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527644582.ch25

Editor Information

  1. 2

    4-2-6 Nishihara, Kashiwa-Shi, Chiba 277-0885, Japan

  2. 3

    DNAFORM Inc., Leading Venture Plaza 2, 75-1 Ono-cho, Tsurumi-ku, Yokohama, Kanagawa 230-0046, Japan

  3. 4

    Mohrmühlgasse 3, 63500 Seligenstadt, Germany

  4. 5

    University of Frankfurt am Main Biocenter, Max-von-Lauestraße 9, 60439 Frankfurt am Main, Germany

  5. 6

    Frankfurt Biotechnology Innovation Center (FIZ), GenXPro Ltd, Altenhöferallee 3, 60438 Frankfurt am Main, Germany

Author Information

  1. CLC bio, Finlandsgade 10–12, Katrinebjerg, 8200 Aarhus N, Denmark

Publication History

  1. Published Online: 23 JAN 2012
  2. Published Print: 14 DEC 2011

ISBN Information

Print ISBN: 9783527328192

Online ISBN: 9783527644582

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Keywords:

  • CLC bio integrated platform;
  • tag sequencing data;
  • main components;
  • features;
  • applications

Summary

High-throughput sequencing of DNA tags is presently becoming technologically and financially accessible to many areas of biomedical research. The new technologies and applications that have emerged offer great promise of exciting new scientific discoveries and are heralding a general shift in biomedical research from a gene-centric to a genome-centric research paradigm. However, a major bottleneck in the dissemination of these technologies is the bioinformatic handling and analysis of sequencing data, and the often insurmountable challenges that researchers face in this area. The CLC bio software platform is developed as an answer to these challenges, and offers researchers an integrated analysis solution that can assist in removing the bioinformatics bottleneck and in optimizing the use of bioinformatics personnel and hardware resources within organizations. Here, we describe the general software platform with special emphasis on the four major tag-sequencing workflows supported: RNA-seq, small RNA-seq, Tag-seq and ChIP-seq.