11. The Diverse Roles of FcRn: Implications for Antibody Engineering

  1. Prof. Dr. Roland Kontermann
  1. E. Sally Ward1 and
  2. Raimund J. Ober1,2

Published Online: 6 FEB 2012

DOI: 10.1002/9783527644827.ch11

Therapeutic Proteins: Strategies to Modulate Their Plasma Half-Lives

Therapeutic Proteins: Strategies to Modulate Their Plasma Half-Lives

How to Cite

Ward, E. S. and Ober, R. J. (2012) The Diverse Roles of FcRn: Implications for Antibody Engineering, in Therapeutic Proteins: Strategies to Modulate Their Plasma Half-Lives (ed R. Kontermann), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527644827.ch11

Editor Information

  1. University of Stuttgart, Institute of Cell Biology and Immunology, Allmandring 31, 70569 Stuttgart, Germany

Author Information

  1. 1

    University of Texas Southwestern Medical Center, Department of Immunology, 6000 Harry Hines Blvd., Dallas, TX 75390, USA

  2. 2

    University of Texas at Dallas, Department of Electrical Engineering, Richardson, TX 75083, USA

Publication History

  1. Published Online: 6 FEB 2012
  2. Published Print: 14 MAR 2012

ISBN Information

Print ISBN: 9783527328499

Online ISBN: 9783527644827

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Keywords:

  • therapeutic proteins;
  • half-life modulation;
  • half-life extension;
  • neonatal Fc receptor;
  • FcRn;
  • antibody engineering;
  • immunoglobulin G

Summary

This chapter contains sections titled:

  • Introduction

  • FcRn: Early Characterization and Diverse Expression Patterns

  • The Molecular Details of FcRn–IgG Interactions

  • FcRn Is Expressed Ubiquitously throughout the Body Where It Serves Multiple Functions

  • The Cell Biology of FcRn and Its Intracellular Transport of IgG

  • The Molecular Determinants of FcRn Trafficking

  • Engineering IgG–FcRn Interactions

  • Inhibitors of FcRn Function

  • Engineering Mice with Altered FcRn Function

  • Concluding Remarks

  • Acknowledgments

  • References