3. Enthalpy–Entropy Compensation as Deduced from Measurements of Temperature Dependence

  1. Prof. Dr. Holger Gohlke
  1. Athel Cornish-Bowden

Published Online: 20 APR 2012

DOI: 10.1002/9783527645947.ch3

Protein-Ligand Interactions, First Edition

Protein-Ligand Interactions, First Edition

How to Cite

Cornish-Bowden, A. (2012) Enthalpy–Entropy Compensation as Deduced from Measurements of Temperature Dependence, in Protein-Ligand Interactions, First Edition (ed H. Gohlke), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527645947.ch3

Editor Information

  1. Heinrich-Heine-Universität, Inst.für Pharmaz. + Med.Chemie, Universitätsstr. 1, 40225 Düsseldorf, Germany

Author Information

  1. CNRS, Bioénergétique et Ingénierie des Protéines, B.P. 71, 31 chemin Joseph-Aiguier, 13402 Marseille Cedex 20, France

Publication History

  1. Published Online: 20 APR 2012
  2. Published Print: 18 APR 2012

Book Series:

  1. Methods and Principles in Medicinal Chemistry

Book Series Editors:

  1. Prof. Dr. Raimund Mannhold3,
  2. Prof. Dr. Hugo Kubinyi4 and
  3. Prof. Dr. Gerd Folkers5

Series Editor Information

  1. 3

    Molecular Drug Research Group, Heinrich-Heine-Universität, Universitätsstrasse 1, 40225 Düsseldorf, Germany

  2. 4

    Donnersbergstrasse 9, 67256 Weisenheim am Sand, Germany

  3. 5

    Collegium Helveticum, STW/ETH Zurich, 8092 Zurich, Switzerland

ISBN Information

Print ISBN: 9783527329663

Online ISBN: 9783527645947

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Keywords:

  • activation energy;
  • compensation temperature;
  • enthalpy;
  • entropy;
  • extrapolation;
  • natural selection;
  • Arrhenius plots;
  • van't Hoff plots

Summary

This chapter contains sections titled:

  • Introduction

  • The Current Status of Enthalpy–Entropy Compensation

  • Measurement of the Entropy and Enthalpy of Activation

  • An Example

  • The Compensation Temperature

  • Effect of High Correlation on Estimates of Entropy and Enthalpy

  • Evolutionary Considerations

  • Textbooks

  • References