4. Interaction Kinetic Data Generated by Surface Plasmon Resonance Biosensors and the Use of Kinetic Rate Constants in Lead Generation and Optimization

  1. Prof. Dr. Holger Gohlke
  1. U. Helena Danielson

Published Online: 20 APR 2012

DOI: 10.1002/9783527645947.ch4

Protein-Ligand Interactions, First Edition

Protein-Ligand Interactions, First Edition

How to Cite

Danielson, U. H. (2012) Interaction Kinetic Data Generated by Surface Plasmon Resonance Biosensors and the Use of Kinetic Rate Constants in Lead Generation and Optimization, in Protein-Ligand Interactions, First Edition (ed H. Gohlke), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527645947.ch4

Editor Information

  1. Heinrich-Heine-Universität, Inst.für Pharmaz. + Med.Chemie, Universitätsstr. 1, 40225 Düsseldorf, Germany

Author Information

  1. Uppsala University, Department of Biochemistry and Organic Chemistry, BMC, Box 576, 75123 Uppsala, Sweden

Publication History

  1. Published Online: 20 APR 2012
  2. Published Print: 18 APR 2012

Book Series:

  1. Methods and Principles in Medicinal Chemistry

Book Series Editors:

  1. Prof. Dr. Raimund Mannhold3,
  2. Prof. Dr. Hugo Kubinyi4 and
  3. Prof. Dr. Gerd Folkers5

Series Editor Information

  1. 3

    Molecular Drug Research Group, Heinrich-Heine-Universität, Universitätsstrasse 1, 40225 Düsseldorf, Germany

  2. 4

    Donnersbergstrasse 9, 67256 Weisenheim am Sand, Germany

  3. 5

    Collegium Helveticum, STW/ETH Zurich, 8092 Zurich, Switzerland

ISBN Information

Print ISBN: 9783527329663

Online ISBN: 9783527645947

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Keywords:

  • HIV protease;
  • ligand;
  • nonnucleoside inhibitors;
  • protein kinase;
  • small-molecule drug discovery;
  • surface plasmon resonance

Summary

This chapter contains sections titled:

  • Background

  • SPR Biosensor Technology

  • From Interaction Models to Kinetic Rate Constants and Affinity

  • Affinity versus Kinetic Rate Constants for Evaluation of Interactions

  • From Models to Mechanisms

  • Structural Information

  • The Use of Kinetic Rate Constants in Lead Generation and Optimization

  • Designing Compounds with Optimal Properties

  • Conclusions

  • Acknowledgments

  • References