16. Consistency of Scale-Up from Bioprocess Development to Production

  1. Dr. Ganapathy Subramanian
  1. Stefan Junne1,
  2. Arne Klingner2,
  3. Dirk Itzeck1,
  4. Eva Brand1 and
  5. Peter Neubauer1

Published Online: 15 OCT 2012

DOI: 10.1002/9783527653096.ch16

Biopharmaceutical Production Technology, Volume 1 & Volume 2

Biopharmaceutical Production Technology, Volume 1 & Volume 2

How to Cite

Junne, S., Klingner, A., Itzeck, D., Brand, E. and Neubauer, P. (2012) Consistency of Scale-Up from Bioprocess Development to Production, in Biopharmaceutical Production Technology, Volume 1 & Volume 2 (ed G. Subramanian), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527653096.ch16

Editor Information

  1. 44 Oaken Grove, Maidenhead, Berkshire SL6 6HH, United Kingdom

Author Information

  1. 1

    Technische Universität Berlin, Department of Biotechnology, Ackerstrasse 71–76, 13355 Berlin, Germany

  2. 2

    Technische Universität Braunschweig, Institute of Biochemical Engineering, Gaussstrasse 17, 38106 Braunschweig, Germany

Publication History

  1. Published Online: 15 OCT 2012
  2. Published Print: 18 JUL 2012

ISBN Information

Print ISBN: 9783527330294

Online ISBN: 9783527653096

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Keywords:

  • scale down;
  • two-compartment reactor;
  • fed-batch processes;
  • process development

Summary

This chapter contains sections titled:

  • Inhomogeneities in Industrial Fed-Batch Processes

  • Effects of Conditions in Industrial-Scale Fed-Batch Processes on the Main Carbon Metabolism

  • Effects of Conditions in Industrial-Scale Fed-Batch Processes on Amino Acid Synthesis

  • Scale-Down Reactors for Imitating Large-Scale Fed-Batch Process Conditions at the Laboratory Scale

  • Improved Two-Compartment Reactor System to Imitate Large-Scale Conditions at the Laboratory Scale

  • Description of the Hydrodynamic Conditions in the PFR Part of the Presented Two-Compartment Reactor

  • Description of Oxygen Transfer in the PFR Part of the Two-Compartment Reactor

  • E. coli Fed-Batch Cultivations in the Two-Compartment Reactor System

  • Future Perspectives for the Application of a Two-Compartment Reactor

  • References