22. Evaluating and Visualizing the Cost-Effectiveness and Robustness of Biopharmaceutical Manufacturing Strategies

  1. Dr. Ganapathy Subramanian
  1. Suzanne S. Farid

Published Online: 15 OCT 2012

DOI: 10.1002/9783527653096.ch22

Biopharmaceutical Production Technology, Volume 1 & Volume 2

Biopharmaceutical Production Technology, Volume 1 & Volume 2

How to Cite

Farid, S. S. (2012) Evaluating and Visualizing the Cost-Effectiveness and Robustness of Biopharmaceutical Manufacturing Strategies, in Biopharmaceutical Production Technology, Volume 1 & Volume 2 (ed G. Subramanian), Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim, Germany. doi: 10.1002/9783527653096.ch22

Editor Information

  1. 44 Oaken Grove, Maidenhead, Berkshire SL6 6HH, United Kingdom

Author Information

  1. University College London, Advanced Centre for Biochemical Engineering, Department of Biochemical Engineering, Torrington Place, London WC1E 7JE, UK

Publication History

  1. Published Online: 15 OCT 2012
  2. Published Print: 18 JUL 2012

ISBN Information

Print ISBN: 9783527330294

Online ISBN: 9783527653096

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Keywords:

  • decision-support tools;
  • process economics;
  • cost of goods (COG);
  • uncertainty;
  • stochastic simulation;
  • multi-criteria decision-making;
  • goal programming;
  • genetic algorithms;
  • process design;
  • capacity planning;
  • portfolio management;
  • disposables;
  • single-use;
  • fed-batch;
  • perfusion;
  • chromatography;
  • contract manufacturing;
  • monoclonal antibody;
  • production;
  • manufacture;
  • mammalian cell culture

Summary

This chapter contains sections titled:

  • Introduction

  • Scope of Research on Decision-Support Tools for the Biotech Sector

  • Capturing Process Robustness Under Uncertainty

  • Reconciling Multiple Conflicting Outputs Under Uncertainty

  • Searching Large Decision Spaces Efficiently

  • Integrating Stochastic Simulation with Multivariate Analysis

  • Conclusions

  • Acknowledgments

  • References